ID G3NZW3_GASAC Unreviewed; 910 AA.
AC G3NZW3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Calcium/calmodulin dependent serine protein kinase {ECO:0000313|Ensembl:ENSGACP00000010886.1};
GN Name=CASK {ECO:0000313|Ensembl:ENSGACP00000010886.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010886.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000010886.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000010886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; G3NZW3; -.
DR STRING; 69293.ENSGACP00000010886; -.
DR Ensembl; ENSGACT00000010909.1; ENSGACP00000010886.1; ENSGACG00000008227.1.
DR eggNOG; KOG0033; Eukaryota.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000155600; -.
DR InParanoid; G3NZW3; -.
DR OMA; STKWASF; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000008227; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12081; SH3_CASK; 1.
DR CDD; cd14094; STKc_CASK; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR035473; CASK_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF40; PERIPHERAL PLASMA MEMBRANE PROTEIN CASK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..259
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 326..381
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 385..438
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 473..554
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 595..665
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 723..895
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 441..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 103462 MW; DE82EED551975A8F CRC64;
VPRGPFSEVR RCINRETGQQ FAVKIVDVAQ FTSSPGLSTE DLKREASICH MLKHPHIVEL
LETYSSDGML YMVFEYMDGA DLCFEIVKRA DAGFVYSEAV ASHYMRQILE ALRYCHDNNV
IHRDVKPHCV LLASKENSAP VKLGGFGVAI QLGESGLVAG GRVGTPHFMA PEVVKREPYG
KPVDVWGCGV ILFILLSGCL PFYGTKERLF EAICRGKYKM NPRQWAQISE SAKDLVRRML
MLDPAERITV YEALNHPWLK ERDRYAYKIH LPETVEQLRK FNSRRKLKGA VLAAVSSHKF
NSFYGDPPEE LHDFSEDPTS SGLLAAERAV SQVLDSLEEI HALTDCSEKD LDFLHSVFQD
QHLHTLLDLY DKINTKSSPQ IRNPPSDAVQ RAKEVLEEIS CYPENHEAKE LRRILTQPHF
MALLQAHDVV AHEVYSDDAL RVTPPPTSPY LNGESPESTN GDMDLENVTR VRLVQFQKNT
DEPMGITLKM NELNHCIVAR IMHGGMIHRQ GTLHIGDEIR EINSISVANQ TVEQLQKMLR
EMRGSITFKI VPSYRTQGSS CEKESPNTSR QSPANGHSSI NSSILDLPST IQPKGRQIYV
RAQFEYDPSK DELIPCKEAG IRFQVGDIIQ IISKDDHNWW QGKLENTKNG TAGLIPSPEL
QEWRVACIAM EKTKQEQQAS CTWFGKKKKQ YKDKYLAKHN AVFDQLDLVT YEEVVKLPAF
KRKTLVLLAG AHGVGRRHIK NTLITKHPDR FAYPIPHTTR PPKKDEEDGK NYYFVSHDQM
MQDISNNDYL EYGSHEDAMY GTRLETIRMI HQHGHIAILD VEPHALKVLR TAEFAPYVVF
IAAPTIAPGI SEDESLQRLQ KESEILQKTY AHCFDQTIIN NEIDETIRHL EEAIDLVCTT
SQWVPVSWVY
//
