ID G3P4E2_GASAC Unreviewed; 613 AA.
AC G3P4E2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=All-trans-retinol 13,14-reductase {ECO:0000256|ARBA:ARBA00041141};
DE EC=1.3.99.23 {ECO:0000256|ARBA:ARBA00038979};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012465.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000012465.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000012465.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol;
CC Xref=Rhea:RHEA:19193, ChEBI:CHEBI:13193, ChEBI:CHEBI:17336,
CC ChEBI:CHEBI:17499, ChEBI:CHEBI:52075; EC=1.3.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00036004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3P4E2; -.
DR STRING; 69293.ENSGACP00000012465; -.
DR Ensembl; ENSGACT00000012489.1; ENSGACP00000012465.1; ENSGACG00000009445.1.
DR eggNOG; KOG4254; Eukaryota.
DR GeneTree; ENSGT00390000017613; -.
DR InParanoid; G3P4E2; -.
DR OMA; AFMFADW; -.
DR TreeFam; TF328375; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009445; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR46091:SF1; ALL-TRANS-RETINOL 13,14-REDUCTASE; 1.
DR PANTHER; PTHR46091; BLR7054 PROTEIN; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..613
FT /note="All-trans-retinol 13,14-reductase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449361"
FT DOMAIN 77..480
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 613 AA; 68517 MW; B27DCABD3216A97D CRC64;
SFLTHLFLTM CRLLVSRCLT VSINYCSGPN PFEKDTREPL KKMVHDRKQK NKVLKQGFLA
SRVPDNLDAI IIGSGIGGLG LGVLLAKVGK KVLVLEQHDR AGGCCHTFTE KGFEFDVGIH
YIGDLLEHKP FRCMLDSMTN GQLQWEPLEN PYDQVVLGPP ENRRKYPIYS GRTRFPEELK
KCFPGEEKAI DEYVRLAKKV GRGIWLLAML KICPVPLAKF LVYTGLAQRL SFFFKMAPRS
LTEVVNELTD NKDLRAVFSY IFGTYGNIPK DSSFAMHSLL VTHYLNGAWY PKGGASEIAY
HMIPIIEKAG GAVLVRAPVN RILFNDSKEA TGVSVMKGQE EMHIHAPMVI SNAGIFNTYQ
KLLPKELQAM PAIQKQTSMM KNGEGGLSVF VGLNGTKEEL GLKADNYWIF AENNFDELVE
KYSNGKREES AHKVPLLFVA SPSAKDPTWE ERSPGKSTVS LVSFANYEWF EEWKDDKVSN
RSPEYKELKQ AFIDSILEVV FDVFPKITRD KVEFIDAGTP ITNTHYIGAP KGEIYGADHG
IARFSPELNA TVRPQTPLKN LYLTGQDVFT CGFAGALAGA LSCGSIILNR NLHLDAIAMA
KKIRFMNPKL KGE
//
