ID G3P681_GASAC Unreviewed; 935 AA.
AC G3P681;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=SLIT and NTRK-like family, member 3b {ECO:0000313|Ensembl:ENSGACP00000013104.1};
GN Name=SLITRK3 {ECO:0000313|Ensembl:ENSGACP00000013104.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000013104.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000013104.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000013104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3P681; -.
DR STRING; 69293.ENSGACP00000013104; -.
DR Ensembl; ENSGACT00000013129.1; ENSGACP00000013104.1; ENSGACG00000009924.1.
DR eggNOG; ENOG502SDHS; Eukaryota.
DR GeneTree; ENSGT00940000158681; -.
DR InParanoid; G3P681; -.
DR OMA; SHSWVRP; -.
DR TreeFam; TF351826; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009924; Expressed in diencephalon and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773:SF9; SLIT AND NTRK-LIKE FAMILY, MEMBER 3B; 1.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..935
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449417"
FT TRANSMEM 669..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..271
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 572..622
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 280..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 935 AA; 103449 MW; 10C80770262F2DD2 CRC64;
RMQWVNLLVA LGCVCLSRAS LVDNSEEEVD EPCFEPCTCE VKEGVLHVHC DGRSFTNASQ
VSQSWVRPFK LNLQRNSLRR LYSNGFQHLG NAVSINLGNN GLQDIRVGAF NGLAKLRRLY
LHENKLEVFR NDTFAGLEAL EYLQADYNVI KRIDSGALRF LYKLRVLILN DNLIPVLPAH
LFRSVSLTHL DLRGNRLKSL AYAGTLEYVG RSLMELQLEE NPWNCGCEAV QLQQWLGQIP
YTAVVGDVTC EYPFHLHGKD LREIPRKELC ANLPDKELQA EGVGGPLAGS QPQHLPPNSK
PNSQPGRVRP TKPSSMVHGS RQNTHTSSTS SSSSAERKDR ERQPRPTKRP RPSRISPTPR
SLMPNQNPPV AGYQTRPPIP IICPMGCTCN LHITDLGLTV NCKENGFLNV SQLTPRPLNG
RKLYLSGNLI QRIYRTDFWN FSSLDLLHLG NNRISYLQEG AFTGLTSLRS LYLNGNNLER
LNPHMFLGLQ NLRFLYFEYN EIHAVDPGTL DSMPSLQLLF LNANLLRSLP LGVFSGVNLA
RLNLRNNHLL HLPMEGVLEH LTGLVQVDLQ QNPWECNCEA APLKRWLEGL SAVVVVGEVV
CHSPEKTKGV DLRSLSMELL CPELEPQEED REQEEQTATS TAADSGVSVG YPGSGLGPLI
PPGKDSIPLS VLVLSLLVLF VSAFFAAAAL IAYALRRRDK LPFRRQGEVD LAGIQMECGI
FTEHLPETPP PPPTEHGHVY DTILPQEAVL KGKGTNPAAG PHMCSNPIYK EEPDAAVKQR
PQQTFVSPKE SKGGYCSAAE KQREWTLEVS SSPINTVTGA MGPLPGLHGN GILCPTVIDS
QGPTPKVELV DCLFRLSAPE FRDLPDRYAR PPPCYPHPQD SNQDARPDET IVVSSAGSAV
GGGNGSQSEQ GAGEQRARLR TTPDYMEVLD RSYQF
//
