ID G3PCZ9_GASAC Unreviewed; 2694 AA.
AC G3PCZ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=ITPR2 {ECO:0000313|Ensembl:ENSGACP00000015473.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000015473.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000015473.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000015473.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR STRING; 69293.ENSGACP00000015473; -.
DR Ensembl; ENSGACT00000015504.1; ENSGACP00000015473.1; ENSGACG00000011693.1.
DR eggNOG; KOG3533; Eukaryota.
DR GeneTree; ENSGT00940000156039; -.
DR InParanoid; G3PCZ9; -.
DR OMA; PLETRAC; -.
DR TreeFam; TF312815; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000011693; Expressed in intestinal epithelial cell and 11 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF3; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2223..2247
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2259..2278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2285..2311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2343..2371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2392..2414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2519..2542
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 113..167
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 232..289
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 2670..2694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2694 AA; 307920 MW; F660A17DFF25A720 CRC64;
MSEHRTSFLH NGDVVSLCAE GSVSGFISTL GLVDDRCVVQ PEAGNLANPP KKFRDCLFKV
CPMNRYSAQK QFWKAKQGKQ GHNNTQGDLF KKLQDAAELE MKQNESENKK LLGEVVKYSN
VIQLLHIKSN KYLTVNKRLP ALLEKNAMRV SLDSAGNEGS WFYIQPFWKL RSEGDNVVVG
DKVVLMPVNA GQPLHASNIE LLDNLGCKEV NAVNCNTSFK ITLFMKFSDY REDVLKGGDV
VRLFHAEQEK FLTCDEYKKQ QQHVFLRTTL RQSATSATSS KALWEIEVVH HDPCRGGAGQ
WNSLFRFKHL ATGNYLAAEE NPEFKDNTVE PKGENETETL FSKRKHQAAE KIAYTLVSVP
HGNDISSLFE LDATTLQRAD CLVPRNSYVR LRHLCTNTWV TSTNVPIDVE EERPVMLKIG
TCCTKEDKEA FAIVSVPLSE VRDLDFANDA SKVLESTVRK LQFGNIAQNE RRFVTKLLED
LVFFVCMVPN NGQDVLSVVT STPNRERQKL MREQNILAQI FGILKAPFTD QGDGPMLKLE
DLGDQRYAHF KYMLRLCYRV LRHSQQDYRK NQEYIAKKFT IMQSQIGYEI LAEDTITALL
HNNRKLLEKH ITAREIETFV SLLRRNREPR FLDYLSDLCV SNKTAIPVTQ ELICKFMLNP
TNADILIQTN RTPYCTPPPP QPRLIPNTET TIESSLWLYW IDGHKEPHGK SIRHLAQDAK
GDNKIDSETI TYYRYQLNLF AKMCLDRQYL AINQITGQLP VDLILRCMFD DCLPYNLRAS
FCRLMLHMHV DRDPQEAVVP VRYARLWTEI PSKITIHEFE YESGDISREE MKRKFAPTME
FVEEYLKDVV NQPFPFGEKD KNELTLEVVN LARNLVYFGF YSFSELLRLT RTLLAILDIV
QHPLTFMNKL DKSPETGNNV LRTIHGVGEM MTQIMMSRGV PHSLPDTSTS LRYARGHFLQ
DNEDVMVMDT KLKIIEILQF ILSVRLDYRI TYLLSIYKKE FGDKVMTDTS ATDFMPLTPS
EPDIDEIATK AESMFAGGSE LSAVELDDEG GRTFLRVLIH LIMQDYPPLV SGSLQLIFKH
FSQRAEVLQA FKQVQLLVSE QDVDNYKQIK ADLDQLRLTV EKSELWVEKS GVYSGEDHGA
GQVNEQNIEV PYHQEVVLSP VQNGDNKPQI DSNKANNYKI VKEILLRLSK LCYPSKKSRV
QQQRLLKNMG AHAVVLDLLQ IPYEKCDEKM NEIMTLAHTF LQNFCKGNHQ NQVLLHKHLN
LFLTPGLLEA ETMRHIFMNN YQLCNEISDR VVHHFVHCIE THGRHVQYLK FLQTIVKEDA
KYVKKCQDKV MTELVNGGED VLVFYNDRSS FSVLLQMMGS ERERMDEDGA LAYHNALVEL
LAACTEGKNV YTELKCNSLL PLDDIVKVVT DIHCIPEVKT AYVNFVNHCY VDTEVEMKEI
YTSNHIWKLF DNFLVDMSSV CNSTTDRNHA DLALEKYVTE TVMAIVKGFF SSPFSVNHSN
LQRNQLVFIK LLQSSFRIYN CPWINSAQKV NIENCIKTLA DVAKARAIAI PVDLDSQVNT
LSLRVHSNMV QRAAKDWRTS ARTRPRKENL GGPDYKNIIE KLQGVVSLLE EQFSPKVQAE
FSVLVDVLHS PELLFPEAAR LRCESGAFMS KLIKHTQKLM EKEEKLCIKI LQTLREMMDK
KECFQEAGSD LRKILLTRYF GTQKLLSKTE LGSGNCSSVS PGGSPMLDLD KPASSLVEIQ
CLLDNVGASE LVIDLIVNTK NDRVFEESIL LGIALLQGGN TQIQNSFYNQ LRKEKKSERF
FKVFYDRMRS AQQEIRATVS VNMFELSCRK REDDTDVSSI RLKKERDSLH IREDMRGQLK
EASSVTSKAF CAYRKELDPD LDGLGQSSEL VGAEDALEET PMSHAITIMK PILRFLQLLC
ENHNTDLQNF LRNQSNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE NNVGLVRQTL
ETITEYSQGP CHENQSCIAK HESNGIDIII ALIVNSINPL EKHRLDLVLE LKNNASKLLL
AIMESRHDSE NAEKILYKMR PTELVDVMKE AYAQGIECED DEDSVGDRIK PRDVGHNIYI
LAHQLARHNK ILQQSLNWGL ARGSCVDPDN EEDEAVHYYA NHTAQIEIVR HDRTMEQIVF
PVPNICEYLT EESMVRVFTT TERDDQGSKV NDFFQQFDNL YNEMRWQKKI RRNKALFWFS
RHISVWGSIS FYLACLLNIA VAVFYPFGDD GDEGTLSPFW NLSLWVALVV FTALLPVLPK
PSGILFFLVS LILRAIYTMG LGPALLLLGA VNLFNKLVFL VSFVGNQGTF TRGYKAVIMD
MLFIYHLGYA IVCVLGLFVH EFFYSFLLFD LVIREETLLN VIKSVTRNGR SIILTAVLAI
FLVYFFSIIG FLFLKDDFRM QVDRLPGPVS VRRSERKEDL LSNKGIAESC LKDKCPVSTP
KNVPVRQMND GTERVCDTLL MCIITVLNQG LRNGGGVGDI LRRPSKAEPL FAARVVYDLL
FFFIVIIIVL NLIFGVIIDT FADLRSEKQR KEEILKTTCF ICGLERDKFD NKTVSFEEHI
KSEHNMWHYL YFLVLVKVKD PTEYTGPESY VAQMITEKNL EWFPRMRAMS LVSSEGDSEQ
NEMRSLQDKL DSTVTLVSQL SGQLAELKEQ MTEQRKNKQR LGLLGPPQAN HLTH
//
