ID   G3PG30_GASAC            Unreviewed;       296 AA.
AC   G3PG30;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=NF-kappa-B inhibitor alpha {ECO:0000256|ARBA:ARBA00041123};
DE   AltName: Full=I-kappa-B-alpha {ECO:0000256|ARBA:ARBA00041987};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016554.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000016554.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000016554.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
CC       {ECO:0000256|ARBA:ARBA00038439}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3PG30; -.
DR   Ensembl; ENSGACT00000016587.1; ENSGACP00000016554.1; ENSGACG00000012514.1.
DR   GeneTree; ENSGT00940000163080; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000012514; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR   PANTHER; PTHR46680:SF1; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          91..123
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          196..228
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          254..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..279
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..296
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  33042 MW;  10A81AA40EB70739 CRC64;
     EERLDSGLDS LKEDEYQAVA AEIRLLQLEC EPPQRGRAAP AAGEPHEWKT QITEDGDTLL
     HLAIIHEAKD YIRTMIDLSK NTDFLNTQND QRQTPLHLAV ITNQAHVCQR LLASGCDPTL
     VDDSGDTPLH IACRHGNLPC FSVLTQNCPL EHLPTVMAAC NYHGQNCLHL ASVQGFLSLV
     ENMVDLGDIN SKEQRNGRSA LHLAVDQQNL SLVQLLLKKG ADPNLLTFGG HTPFHLTYGR
     NDNDIRKELY SLTDPALRDL PDSESDNSEE EEDESDEESL EKPQDNKVLG WKRSEL
//