ID G3PJB5_GASAC Unreviewed; 964 AA.
AC G3PJB5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 1 {ECO:0000313|Ensembl:ENSGACP00000017694.1};
GN Name=GABBR1 {ECO:0000313|Ensembl:ENSGACP00000017694.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017694.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017694.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; G3PJB5; -.
DR Ensembl; ENSGACT00000017729.1; ENSGACP00000017694.1; ENSGACG00000013381.1.
DR GeneTree; ENSGT00940000157642; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013381; Expressed in telencephalon and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15291; 7tmC_GABA-B-R1; 1.
DR CDD; cd00033; CCP; 2.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SMART; SM00032; CCP; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 566..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..133
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 573..879
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 869..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 104..131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 964 AA; 108728 MW; 6BE910D84419D058 CRC64;
SVGCAIIRPP RDGGIRYRGL TQEQIRSVQI LPVDYEIEYI CRGNRVIVGP KVRKCLPNGT
WTDITLNSTC LLLCPRVWTS LENGRVTVKP PGPPVEGTVL HYSCHAGFIL EGRNISHCTK
LGKWDAPKPT CLFNTFTHKS KKKLYIGALF PMSGGWHGGQ ACMPSAQMAL DLVNNRSDIL
PDYELELIHY DSMCDPGEAT KLLYDLLYTE PIKIVLLPGC SGVSTLVAEA ARMWNLIVTS
RGSRSPALSK RQRFPTFFRT HPSATLHKPP RVQLFQKWKW TRIATIQQNT EVFTSTLDDL
EERTKEAGIE ISVRQSFLTD PAVAVKNLKR QDARIIVGLF YETEARKVFC EVFKEKLYGK
KYVWFLIGWY ADNWFKIKDP AINCTVENMT EAVEGHVTTE IVMLNPETVR GVSNMTSQEF
IAALMSRLGG KNPEETGGFQ EAPLAYDAVW ALALALNKTV APLKAKGRRL EDFNYNNHDI
TSEIYRALNT SSFEGVSGQV VFDAQGSRMA MTLIEQLQGG SYKKIGYYDS SQKNLSWFGN
DVWIGAGPPA DRTVVIEVYR FLSQKLFAAV SVFAGLGILF GIVCLTFNIY NGNVRYIQNS
QPYLNNMTAV GCMMALAAVF PLGIDGHHVH RSQFPVVCQF RLWLLGLGFS LAYGSMFTKI
WWVHTLFTKK DEKKEYRQHL EPWKLYATVG VLLAIDFLSL MIWQIVDPLH ITVEKFTKEA
PKEDLDVLIQ PLLEHCSSEK MNTWLGIHWA YAVLRSLNGR RTHIILCPPP LSVGVVYGYK
GLLLLLGIFL AYETKSVSTE KINDHRAVGM AIYNVAVLCL ITAPVTMILS SQQDASFAFA
ALAVVFSAYI TLVVLFVPKM RRLITRGEWQ SEQQDTLKTG SSTNNNDEEK SRQLERENRE
LQKIIQEKEE RVSALRNQLA ERQALRNRRQ PSSGQNQNHN TPPPSTQPPD PNHCHNSQIP
LLYK
//
