ID G3PLJ7_GASAC Unreviewed; 1146 AA.
AC G3PLJ7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Si:dkey-21e5.1 {ECO:0000313|Ensembl:ENSGACP00000018478.1};
GN Name=KCNT1 {ECO:0000313|Ensembl:ENSGACP00000018478.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000018478.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000018478.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000018478.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G3PLJ7; -.
DR STRING; 69293.ENSGACP00000018478; -.
DR Ensembl; ENSGACT00000018514.1; ENSGACP00000018478.1; ENSGACG00000013992.1.
DR eggNOG; KOG3193; Eukaryota.
DR GeneTree; ENSGT00940000156880; -.
DR InParanoid; G3PLJ7; -.
DR OMA; WADRYLL; -.
DR TreeFam; TF314283; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013992; Expressed in diencephalon and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF14; POTASSIUM CHANNEL SUBFAMILY T MEMBER 1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..263
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 420..514
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 591..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 130551 MW; 219EA3973E3F855C CRC64;
RVQVEFYVNE NTFKERLKLF FIKNQRSSLR IRLFNFSLKV LTCALYILRV SLDDPNGVNG
DPCAICRSNN NTAASGDINW SLIFWVTRRE PVWAIQVTVA LISFLETMLI TYLSYKGNIW
EQIFQISFIL EMINSVPFII TIFWPPLRNI FVPVFLNCWL AKGALENMIN DFHRAIQRTH
SAMFNQVFIL ICTLFCLVFT GACGIQHLER AGKHLGLFDA FYFCIVTFST VGYGDVTPQI
WPSQLLVVIL ICVALVVLPL QFEELAYLWM ESQKLGGNYS RHRAQTEKHV VLCVSSLKID
LLMDFLNEFY AHPRLQDYYV VILCPTEIDI QVRRILQIPL WSQRVIYLQG SALKDQDLMR
AKMDDAEACF ILSSRNEVDR TAADHQTILR AWAAKDFAPN CPLYVQILKP ENKFHVKFAD
HVVCEEEFKY AMLALNCVCP ATSTLVTLLV HTSRGQEGQL SPEQWQRIYG RCSGNEVYHI
RLCDSKFFGE YDGKSFTYAS FHAHKKYGVC LIGVKREDNK SILLNPGPRH IMAAADTCYY
INITKEENSA FIFKEEEKHN KGLSVSGLYD APCRLPVHSI IASMGTVAID LQNPDPPEES
GKLTLPTENG SGSRRPSIAP VLEIADSSAI LPCDLLSDQS EDETNQSDDE GSVAPDFVKG
YPPNSPYIGS SPTLCHLLPQ KAPFCCLRLD KGCTHSSFVD AKAYGFKNKL IIVSAETAGN
GLYNFIVPLR AYYRPRKELN PIVLLLDYQP DNHFLEAICC FPMVYFMAGT IDNQWTSLDN
LLQCGIIYAD NLVVVDKEST MSAEEDYMAD AKTIVNVQTM FRLFPSLSII TELTHPSNMR
FMQFRAKDCY SLALSKLEKV ERDKGSNLAF MFRLPFAAGR VFSISMLDTL LYQSFVKDYM
IGIARLLLGL DTTPGSGYLC AMKITEEDLW IRTYGRLFQK LCSSSAEIPI GIYRTESHMF
ATSESQVSIN TQQGEEPRER GEPWKEKAAH RNSTASDQSE HPLLRKKSMQ WARRLSRKTN
KPSSRAERIS QQRLNLYRRS ERQELSELVK NRMKHLGLPT VGYEDVSNLT ASDVMNRVNL
GYLQDEMNDH QNTLSYVLIN PPPDTMLELN DIVYIIRSDP LAHMPDDSQS RNRQDFGTET
RDETHL
//
