ID G3PRP8_GASAC Unreviewed; 979 AA.
AC G3PRP8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000020284.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000020284.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000020284.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Early endosome {ECO:0000256|ARBA:ARBA00004412}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; G3PRP8; -.
DR STRING; 69293.ENSGACP00000020284; -.
DR Ensembl; ENSGACT00000020323.1; ENSGACP00000020284.1; ENSGACG00000015381.1.
DR eggNOG; KOG0196; Eukaryota.
DR GeneTree; ENSGT00940000163892; -.
DR InParanoid; G3PRP8; -.
DR OMA; PGEYPWP; -.
DR TreeFam; TF315608; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000015381; Expressed in telencephalon and 2 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005003; F:ephrin receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
DR InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF18; EPHRIN TYPE-A RECEPTOR 4; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
DR PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000666-
KW 2}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000666-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000666-2}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 521..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..179
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 298..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 414..510
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 616..878
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 903..967
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT BINDING 648
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-2"
FT DISULFID 43..161
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
FT DISULFID 78..88
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
SQ SEQUENCE 979 AA; 109050 MW; 2EFA23E42197BC7E CRC64;
VTLLDTRTVP GELKWAASPS EGGWEEVSIM DEKNIPIRTY QVCNVLEPNQ NNWLRTDWIP
RSGAQRVYVE VKFTLRDCNS LPGVTGTCKE TFNLYYHESN EDRESYIKES SFIKVDTVAA
DESFTQVDVG DRIMKLNTEV RDVKVATRKG FYLAFQDVGA CIALVSVRVF YKTCPLTIRN
LATFPDTVTG ADTSSLVEVR GSCVNRSEER EEPKMYCGAD GEWLVPIGGC FCSPGYQEKG
GTCKACSVGF YKAKSPDAGC SKCPPHSHSL RDGATVCDCH SAFFRADSDP PSMACTQPPS
APQQLISVVN ETSVVLEWAP PRRLGGRSDT SYSLECLICP TASRSHTGLC LPCSSDVVFS
PDQAGLKTTR VVVSELRAHT HYTFIVHARN GVSRASGAGA AQSVSVTVTT NQAAPSAVSS
ILAIDVTRHS LALSWQQPDR PNGVILEYEV KFYEKDQKER SYRIMRTFSR SVDVTGLNPL
TVYVFHVRAR TAAGYGEFSP PFESATSSDP FPLIGEGVNT AFLLLSVSGV GILLLISAAV
FIISRRCSIQ TCFYTNTLVS LPSLNRRSKY SKTKQDSEEE KHLNPGVKIY VDPFTYEDPD
QAIHEFAKEI DVSSIHIERV IGMVGEFGEV CSGRLRVQGK REIYVAIKSL KAGYSDKQRR
DFLSEASIMG QFDHPNIIRL EGVVTRCKPL MIITEYMENG SLDAFLRRTA HKPSTDDLHT
ILVAFPSINE VLLDEKMKHT ELQAADYCHV AFSCQFTYLP NLSRYLDHYE ATGTYLSPGG
KIPIRWTAPE AIAYRKFTTA SDVWSYGIVM WEVVSYGERP YWDMNNQDVI KAIEEGYRLP
APMDCPVVLH QLMLDCWERE RAERPTFSQI LNMLDKLIRN PGTLRRTGVG SEVRVSVLPE
VCVPAGSVCE WLRSLGLERY RDTLAAAGYT SIDTLLALTH QEMDRLGIIT PSHQDLLIAS
VQQEVLSQMR HMQHTMVPV
//
