ID G3PWJ3_GASAC Unreviewed; 847 AA.
AC G3PWJ3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Interferon-induced GTP-binding protein Mx {ECO:0000256|ARBA:ARBA00015210};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
DE AltName: Full=Interferon-inducible Mx protein {ECO:0000256|ARBA:ARBA00031810};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021982.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021982.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021982.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR AlphaFoldDB; G3PWJ3; -.
DR STRING; 69293.ENSGACP00000021982; -.
DR Ensembl; ENSGACT00000022023.1; ENSGACP00000021982.1; ENSGACG00000016647.1.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000155214; -.
DR InParanoid; G3PWJ3; -.
DR OMA; MQMVQTF; -.
DR TreeFam; TF300362; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016647; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF32; DYNAMIN-1; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 28..296
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 521..627
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 662..753
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 633..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..836
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 95307 MW; 8BEA782F80B27D1D CRC64;
MGNQGMEDLI PLVNRMQDAF SAIGQNSNLD LPQIAVVGGQ SAGKSSVLEN FVGKDFLPRG
SGIVTRRPLV LQLMNCPTEY AEFLHCKGKK FVDFDEVRQE IEAETDRITG ANKGISAVPI
NLRVYSPNVL NLTLVDLPGM TKVPVGDQPA DIEAQIREML MQFVTKENCL MLAVSPANSD
LANSDALKIA KEVDPQVGMR TIGVITKLDL MDEGTDAKDI LENKLLPLRR GGYIGVVNRS
QKDIDGRKDI NAAMTAERKF FLSHPSYRHL ADRMGTPYLQ KILNQQLTNH IRDTLPNLRA
KLQSQLLSIE KEVEEYKNFR PDDPSRKTKA LLQMVQQFSV DFEKCIEGSG DQIDTAELSG
GARINRIFHE RFPFELVKME FDEKELRKEI SYAIKNIHGI RTGLFTPDMA FETIVKRQIG
KIKEPCAKCV DMVISELVIT VRQCTKKLAQ YPSLREEMER IVTQHIRDRE NRTKNQVMLL
IDIELSYMNT NHEDFIGFAN AQQRINQMNK KKAAGNQDEI MVIRKGWLTI NNISIMKGGA
KEYWFVLTAE SLSWYKDDEE KEKKYMLQVD NLKLRDVEKG FMSSKQIFAL FNTEQRNVYK
DYRQLELACE TQEDIDAWKA SFLRAGIYPE RVTDKEGKSD GGDENGSDNI MHSMDPQLER
QVETIRNLVD SYMAIVNKTV RDLMPKTIMH LMINNTKEFI NADLLAQLYS CGDQNTLMEE
SQEQAQHRDE MLRMYHALRE ALSIIGDIST STITTNMPRP GDDSGLQGQR SGPGERSPAT
SPTPNRRAPP GRPGSRGPPP GPPPAGGPPV PSRPGASPDP YSGPPPTVPS RPNRAPPSVP
RITITDQ
//
