ID G3PYE0_GASAC Unreviewed; 758 AA.
AC G3PYE0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Discs, large homolog 3 (Drosophila) {ECO:0000313|Ensembl:ENSGACP00000022630.1};
GN Name=DLG3 {ECO:0000313|Ensembl:ENSGACP00000022630.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022630.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000022630.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000022630.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3PYE0; -.
DR Ensembl; ENSGACT00000022673.1; ENSGACP00000022630.1; ENSGACG00000017128.2.
DR GeneTree; ENSGT00940000159565; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017128; Expressed in telencephalon and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12029; SH3_DLG3; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035763; DLG3_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF28; DISKS LARGE HOMOLOG 3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 46..133
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 141..228
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 301..382
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 416..486
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 568..743
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 758 AA; 84061 MW; D341F25478409760 CRC64;
LPASHNNITC ISSSSQANPP PIIVNADSID AGPYVNGSDG MYKYEEIILE RGNSGLGFSI
AGGIDNPHIP DDPGIFITKI IPGGAAAMDG RLGVNDCVLR VNEVDVSEVV HSRAVEALKE
AGPVVRLLVR RRQAPPETIL EVNLLKGPKG LGFSIAGGIG NQHIPGDNSI YITKIIEGGA
AQKDGRLQTG DRLLAVNNIV LQDVRHEEAV AALKNTSDMV YLKVAKPGPV HLNDMYAPPD
YSSSTYLPPF PTMVDNHVGH NYMGAMEPKP VYPPPQVTPS RYSPVPRHML GEEDFTREPR
KVLLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LRRGDRILSV NGVNLRNATH
EQAAAALKRA GQTVTIIAQY RPEEYSRFES KIHDLREQMM NSSMSSGSGS LRTSEKRSLY
VRALFDYDRT RDSCLPSQGL SFSYGDILHV INASDDEWWQ ARLVTPHGES EQIGVIPSKK
RVEKKERARL KTVKFHARTG MIESNRVRTG VFFFRRLLRQ VFKCSVTRSC APAECLTSNT
SDSESSSKGQ EDTILSYEPV IRQEIHYTRP VIILGPMKDR VNDDLISEFP HKFGSCVPHT
TRPRRENEMD GQDYHFVGSR EQMEKDIQDN KFIEAGQFNE NLYGTSILSV RTVAERGKHC
ILDVSGNAIK RLQQAQLYPI AIFIKPKSIE ALMEMNKRQT YEQANKVFDK AVKLEQDFGE
YFTAIVQGDS LEEIYNKIKL IIEEQSGPYI WIPSSEKL
//
