ID G3PZD6_GASAC Unreviewed; 668 AA.
AC G3PZD6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=SH2 domain containing 3Ca {ECO:0000313|Ensembl:ENSGACP00000022976.1};
GN Name=SH2D3C {ECO:0000313|Ensembl:ENSGACP00000022976.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022976.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000022976.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000022976.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3PZD6; -.
DR STRING; 69293.ENSGACP00000022976; -.
DR Ensembl; ENSGACT00000023019.1; ENSGACP00000022976.1; ENSGACG00000017388.1.
DR eggNOG; ENOG502QPX3; Eukaryota.
DR GeneTree; ENSGT00940000154130; -.
DR InParanoid; G3PZD6; -.
DR OMA; MVHNSRM; -.
DR TreeFam; TF323756; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017388; Expressed in spleen and 8 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 39..138
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 394..662
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 224..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 74601 MW; 8034AAA2BB09449D CRC64;
CSTQFSKEKY LLESPPEKLR KELEEELKLS AADIRSHGWY HGHIPREVSE TLVVRNGDFL
VRDSLAGVGD YVLTCRWDNE VLHFKISKVL VRTVDAFTQV QYVLEADSFD SVQELVRFYI
GQRKPVSQSS GVHIYCPVSR TLPLRYLEAT FALAASKQSS AYSPSSQRGA YIKRRSVTMN
DGLTMDKMIS HRCCVFSPST IHHHKDAMRN CAMSMDQIQE YRRPLSPVGE TPRSPAYSAT
VTRQRAHSSG RVLAVVPPSP QMRRSSDPEL SPPAGNNPAE HPAHTSHPPH SAPARHPGHQ
THSSETAGSY CDLRPCPAGP PKPPNKSYVE RLRVEDGRAD GARVEGEGVF SAPQVETASS
FRPSRYASCL MPADNKPLEM SVLKRVKELL AEVDARTAAV HITMADCTVA RILGVTTELQ
RMMGVSSGLE LLTLPHGHQL RLDLLERFYT MSIMMAVDLL GCTGSTEERA ALLHKTIQLA
AELKSNLGNM FGFAAVMRAL ELPQISRLEQ TWVTLRQRHT EGAILYEKKL KPFMKNMNDG
KESNALANTS VPHIIPILSL LERGMAVGEA LEPWESAEVG VDVVMYHLEA ARTMAHHGGI
YRSNTETKLQ GFQERAEIHE IFQTEFQMRL LWGSRGSEGS QSERYEKFDK VLTALSYKLE
PPVRHSEL
//
