ID G3Q122_GASAC Unreviewed; 753 AA.
AC G3Q122;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000023570.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000023570.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000023570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
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DR AlphaFoldDB; G3Q122; -.
DR STRING; 69293.ENSGACP00000023570; -.
DR Ensembl; ENSGACT00000023616.1; ENSGACP00000023570.1; ENSGACG00000017826.1.
DR eggNOG; KOG0925; Eukaryota.
DR GeneTree; ENSGT00940000155800; -.
DR InParanoid; G3Q122; -.
DR OMA; MKVYPLY; -.
DR TreeFam; TF105735; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017826; Expressed in embryo and 13 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF95; ATP-DEPENDENT RNA HELICASE DHX15; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 105..271
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 296..476
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 86465 MW; 2AEABB60C509718F CRC64;
MSKRHRLDLG EDYSTKKRSE GRDRDRDRED RSRDRERDRD RDRDPKPTNV PSNSTVPLPC
LAPIKQLAMQ QQINPFTNLP HTPRFYEILK KRLQLPVWEY KERFGDIITR HQSFVLVGET
GSGKTTQIPQ WCVDMVRGLP GPKRAVACTQ PRRVAAMSVA QRVADEMDVM LGQEVGYSIR
FEDCSSAKTI LKYMTDGMLL REAMNDPLLE RYGVIILDEA HERTLATDIL MGVLKEVVRQ
RGDLKVIVMS ATLDAGKFQV YFDNCPLLTI PGRTHPVEIF YTPEPERDYL EAAIRTVIQI
HMCEEDEGDC LLFLTGQEEI DEACKRIKRE VDDLGPDVGD IKIIPLYSTL PPQQQQRIFE
PPPPRKPNGA IGRKVVVSTN IAETSLTIDG VVFVIDPGFA KQKVYNPRIR VESLLVTAIS
KASAQQRAGR AGRTRPGKCF RLYTEKAYKT EMQDNTYPEI LRSNLGSVVL QLKKLGIDDL
VHFDFMDPPA PETLMRALEL LNYLAALNDD GDLTELGSMM AEFPLDPQLA KMVIASCEFN
CSNEILSITA MLSVPQCFVR PTEAKKAADE SKMRFAHIDG DHLTLLNVYH AFKQNHEANQ
WCYDNFVNYR SLMSADNVRQ QLSRIMDRFN LPRRSTEFTS RDYYTNIRRA LCTGFFMQVA
HLERTGHYLT VKDNQVVQLH PSTVLDHKPE WVLYNEFVLT TKNYIRTCTD IKPEWLVKIA
PQYYEMSNFP QCEAKRQLER IVAKLESKEY SQY
//
