ID   G3QAM3_GASAC            Unreviewed;       798 AA.
AC   G3QAM3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 2b {ECO:0000313|Ensembl:ENSGACP00000026939.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000026939.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000026939.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000026939.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3QAM3; -.
DR   STRING; 69293.ENSGACP00000026939; -.
DR   Ensembl; ENSGACT00000026991.1; ENSGACP00000026939.1; ENSGACG00000020381.1.
DR   eggNOG; KOG3609; Eukaryota.
DR   GeneTree; ENSGT01060000248588; -.
DR   InParanoid; G3QAM3; -.
DR   OMA; MIDDMMF; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005458; TRPC2_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117:SF6; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; 1.
DR   PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01643; TRPCHANNEL2.
DR   SMART; SM01420; TRP_2; 1.
DR   SUPFAM; SSF140860; Pseudo ankyrin repeat-like; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        536..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        604..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          174..236
FT                   /note="Transient receptor ion channel"
FT                   /evidence="ECO:0000259|SMART:SM01420"
SQ   SEQUENCE   798 AA;  92078 MW;  2042AABE7FE609AA CRC64;
     MENLTPEQWR EIMSRKMRFP PELIGAIQEG KIELLCGLLK TGDGIIRQLD ESEDRQWREA
     LNLSIRLGNE SCMDALLQGV KFDFRQIHEA LLVAVDTNQP RVVKRLLDRL DQEKGNKMDV
     RSFSQAIFDH SIDNSQFAPG VTPLTLACQK DLYDIVTMLT KKGHIIPWPH KISCACLECR
     NGRQYDLLKF SLSRINTYRG IASRAYLSIT SEDAMLRAFS LSRELRKLSQ KEPEFKPQYL
     GLEELCQEFA VELLGMCRNQ SEVTTILNSC GDESQDSLEE QAFEEGIPNL SRLRLAVNYN
     QKQFVAHPIC QQVLSSIWCG NLAGWRGSRT AWKLLVSLGI FFTMPFLCLV YWIAPKSKFG
     KVIKTPVIKF LLHSASYLWF LITLLGESMA MEIHQGKFSS RQQNMLHSSF HMVWVVGFFW
     YECKEVWIEG LRCYFLDWWN CLDVMVLSMY LASFALRLLI MLKGYFLCRD LDGADECTYF
     TQTERKDWHQ EDPQLIAEVL FAVTSMLSFT RLAYILPAHE SLGTLQISIG KMIDDMMRFM
     FILMIIGTAF LCGLNNVYVP YAISPHLGRF NETFHFLFWT MFGVANQDYV DMPQFALAEF
     VGRVLYGIFT LVIVIVLLNM LIAMITNSFQ KIEDDADVEW KFARSKLYLS YFREGLTIPV
     PFNIIPSPKA VFYILRCIFR QICCCCTFNS ENKYPDLPSM VRSKDKVSEG SQLPYRQQVI
     RALVQRYIES ARREFEETKR KDIGNRITSL TKTVTRMHSD MKVLHQVLMD DGRAASDALT
     RDGSSFLGKY IVGAKNNF
//