ID   G3QAP6_GASAC            Unreviewed;       290 AA.
AC   G3QAP6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Hydroxysteroid (20-beta) dehydrogenase 2 {ECO:0000313|Ensembl:ENSGACP00000026962.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000026962.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000026962.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000026962.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|RuleBase:RU000363}.
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DR   AlphaFoldDB; G3QAP6; -.
DR   Ensembl; ENSGACT00000027014.1; ENSGACP00000026962.1; ENSGACG00000020397.1.
DR   GeneTree; ENSGT00940000163913; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000020397; Expressed in heart and 3 other cell types or tissues.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05356; 17beta-HSD1_like_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43899:SF10; 20BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; 1.
DR   PANTHER; PTHR43899; RH59310P; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
SQ   SEQUENCE   290 AA;  32494 MW;  95B0F99D42F83F32 CRC64;
     TMSFTDKLAV IGGFTVVFQL LRLAWRCWCG FRQFVLSELW HVDLKTYGQW AVVTGATSGI
     GKAYARELAQ RGLDVILVSR CDDKLRMIAK EIEEQYGQKT RTIQVDFTDS QRIYPAIAKQ
     LEGLEIGILV NNVGMTYSDH FAYFLEIPDA EQKITQIINC NMLSVPQMTR LVLPGMVERG
     IGLIVNMSSE VGVRPQPLLS LYCATKSFVT FFSQCLHAEY KSKGIIVQCV APFMVSTNMT
     KHRTVNFFVR SASGFAREAL NTVGQSSYTS GCLSHALQNT ALTILLPDWF
//