ID G3QHW9_GORGO Unreviewed; 1168 AA.
AC G3QHW9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Tubulin-specific chaperone D {ECO:0000256|ARBA:ARBA00015003};
GN Name=TBCD {ECO:0000313|Ensembl:ENSGGOP00000001956.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000001956.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000001956.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000001956.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000001956.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TBCD family.
CC {ECO:0000256|ARBA:ARBA00006853}.
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DR EMBL; CABD030035596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030035597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030035598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030035599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030035600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030035601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030035602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QHW9; -.
DR Ensembl; ENSGGOT00000001998.3; ENSGGOP00000001956.3; ENSGGOG00000001984.3.
DR eggNOG; KOG1943; Eukaryota.
DR GeneTree; ENSGT00390000017103; -.
DR HOGENOM; CLU_003043_1_0_1; -.
DR TreeFam; TF105754; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000001984; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033162; TBCD.
DR InterPro; IPR022577; Tubulin_specific_chaperoneD_C.
DR PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR Pfam; PF12612; TFCD_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 881..1063
FT /note="Tubulin-specific chaperone D C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12612"
SQ SEQUENCE 1168 AA; 129548 MW; 88462FA181C246DC CRC64;
MALSDEPAAG GPEEEAEDET LAFGAALEAF GESAETRALL GRLREVHGGG AEREVALERF
RVIMDKYQEQ PHLLDPHLEW MMNLLLDIVQ DQTSPASLVH LAFKFLYIIT KVRGYKTFLR
LFPHEVADVE PVLDLVTIQN PKDHEAWETR YMLLLWLSVT CLIPFDFSRL DGNLLTQPGQ
TRMSIMDRIL QIAESYLIVS DKARDAAAVL VSRFITRPDV KQSKMAEFLD WSLCNLARSS
FQTMQGVITM DGTLQALVIQ FLFAAATVLR CLDGCRLPES NQTLLRKLGV KLVQRLGLTF
LKPKVAAWRY QRGCRSLAAN LQLLTQGQSE QKQLILTEED EDGDVPEGVE RVIEQLLVGL
KDKDTVVRWS AVSVAAEAPR GVGRPLTIFV ALSFQETDKA WHGGCLALAE LGRRGLLLPS
RLVDVVAVIL KALTYDEKRG ACSVGTNVRD AACYVCWAFA RAYEPQELKP FVTAISSALV
IAAVFDRDIN CRRAASAAFQ ENVGRQGTFP HGIDILTTAD YFAVGNRSNC FLVISVFIAG
FPEYTQPMID HLVTMKINHW DGVIRELAAK ALHNLAQQAP EFSATQVFPR LLSMTLSPDL
HTRHGSILAC AEVAYALYKL AAQENRPVTD HLDEQAVQGL KQIHQQVCLG LGGQLMRQAV
CVLIEKLSLS KMPFRGDTVI DGWQWLINDT LRHLHLISSH SRQQMKDAAV SALAALCSEY
YMKEPGEADP AIQEELITQY LAELRNPEEM TRCGFSLALG ALPGFLLKGR LQQVLTGLRA
VTHTSPEDVS FAESRRDGLK AIARICQTVG VKAGAPDEAV CRENVSQIYC ALLGCMDDYT
TDSRGDVGTW VRKAAMTSLM DLTLLLARSQ PELIEAHICE RIMCCVAQQA SEKIDRFRAH
AASVFLTLLH FDSPPIPHVP HRGELEKLFP RSDVASVNWS APSQAFPRIT QLLGLPTYRY
HVLLGLVVSL GGLTESTIRH STQSLFEYMK GIQSDPQALG SFSGTLLQIF EDNLLNERTE
LTFFETEKVC IPGLVCCSSS HPFAVKLLAL CKKEIKNSKD IQKLLSGIAV FCGMVQFPGD
VRRQALLQLC LLLCHRFPLI RKTTASQVYE TLLTYSDVVG ADVLDEVVTV LSDTAWDAEL
AVVREQRNRL CDLLGVPRPQ LVPQPGAC
//
