ID G3QI82_GORGO Unreviewed; 1289 AA.
AC G3QI82;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Regulatory factor X7 {ECO:0000313|Ensembl:ENSGGOP00000002086.3};
GN Name=RFX7 {ECO:0000313|Ensembl:ENSGGOP00000002086.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002086.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002086.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002086.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000002086.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030096417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030096418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000002131.3; ENSGGOP00000002086.3; ENSGGOG00000002118.3.
DR GeneTree; ENSGT01050000244970; -.
DR Proteomes; UP000001519; Chromosome 15.
DR Bgee; ENSGGOG00000002118; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF2; DNA-BINDING PROTEIN RFX7; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 11..90
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 216..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..870
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1289 AA; 138968 MW; EA7D08DD58BDA1FD CRC64;
MSSSRAQQMH AFSWIRNTLE EHPETSLPKQ EVYDEYKSYC DNLGYHPLSA ADFGKIMKNV
FPNMKARRLG TRGKSKYPLP EWCYGLRKKA FVHMPTLPNL DFHKTGDGLE GAEPSGQLQN
IDEEVISSAC RLVCEWAQKV LSQPFDTVLE LARFLVKSHY IGTKSMAALT VMAAAPAGMK
GITQPSAFIP TAESNSFQPQ VKTLPSPIDA KQQLQRKIQK KQQEQKLQSP LPGESAAKKS
ESATSNGVTN LPNGNPSILS PQPIGIVVAA VPSPIPVQRT RQLVTSPSPM SSSDGKVLPL
NVQVVTQHMQ SVKQAPKTPQ NVPASPGGDR SARHRYPQIL PKPANTSALT IRSPTTVLFT
SSPIKTAVVP ASHMSSLNVV KMTTISLTPS NSNTPLKHSA SVSSAAGTTE ESRSVPQIKN
GSVVSLQSPG SRTSSAGGTS AVEVKVEPET SSDEHPVQCQ ENSDEAKAPQ TPSALLGQKS
NTDGALQKPS NEGVIEIKAT KVCDQRTKCK SRCNEMLPGT STGNNQSTIT LSVASQNLTF
TSSSSPPNGD SINKDPKLCT KSPRKRLSST LQETQVPPVK KPIVEQLSAA TIEGQKQGSV
KKDQKVPHSG KTEGSTAGAQ IPSKVSVNVN SHIGANQPLN SSALVISDSA LEQQITPSSS
PDIKVKLEGS VFLLDSDSKS VGSFNPNGWQ QITKDSEFIS ASCEQQQDIS VMTIPEHSDI
NDLEKSVWEL EGMPQDTYSQ QLHSQIQESS LNQIQAHSSD QLPLQSELKE FEPSVSQTNE
SYFPFDDELT QDSIVEELVL MEQQMSMNNS HSYGNCLGMA LQSQSVTPGA PMSSHTSSTH
FYHPIHSNGT PIHTPTPTPT PTPTPTPTPT PTSEMIAGSQ SMSRESPCSR LAQTTPVDSA
LGSSRHTPIG TPHSNCSSSV PPSPVECRNP FAFTPISSSM AYHDASIVSS SPVKPMQRPM
ATHPDKTKLE WMNNGYSGVG NSSVSGHGIL PSYQELVEDR FRKPHAFAVP GQSYQSQSRH
HDTHFGRLTP VSPVQHQGAT VNNTNKQEGF AVPAPLDNKG TNSSASSNFR CRSVSPAVHR
QRNLSGSTLY PVSNIPRSNV TPFGSPVTPE VHVFTNVHTD ACANNIAQRS QSVPLTVMMQ
TAFPNALQKQ ANSKKITNVL LSKLDSDNDD AVRGLGMNNL PSNYTARMNL TQILEPSTVF
PSANPQNMID SSTSVYEFQT PSYLTKSNST DQINFSPGDN QAQSEIGEQQ LDFNSTVKDL
LSGDSLQTNQ QLNKPSILGI GYFVVGIVF
//
