ID G3QJM9_GORGO Unreviewed; 1184 AA.
AC G3QJM9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Diaphanous related formin 1 {ECO:0000313|Ensembl:ENSGGOP00000002628.3};
GN Name=DIAPH1 {ECO:0000313|Ensembl:ENSGGOP00000002628.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002628.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002628.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002628.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000002628.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; CABD030041382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030041383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030041384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030041385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030041386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QJM9; -.
DR Ensembl; ENSGGOT00000002682.3; ENSGGOP00000002628.3; ENSGGOG00000002660.3.
DR eggNOG; KOG1924; Eukaryota.
DR GeneTree; ENSGT00940000159910; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR TreeFam; TF315383; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000002660; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF4; PROTEIN DIAPHANOUS HOMOLOG 1; 1.
DR Pfam; PF06346; Drf_FH1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 40..401
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 677..1083
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1106..1134
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 426..520
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 950..977
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1060..1104
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..658
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 132619 MW; A5BCE1C1F27D73AF CRC64;
MADELERFTS MRIKKEKEKP NSAHRNSSAS YGDDPTAQSL QDVSDEQVLV LFEQMLLDMN
LNEEKQQPLR EKDIIIKREM VSQYLYTSKA GMSQKESSKS AMMYIQELRS GLRDMPLLSC
LESLRVSLNN NPVSWVQTFG AEGLASLLDI LKRLHDEKEE TAGSYDSRNK HEIIRCLKAF
MNNKFGIKTM LETEEGILLL VRAMDPAVPN MMIDAAKLLS ALCILPQPED MNERVLEAMT
ERAEMDEVER FQPLLDGLKS GTTIALKVGC LQLINALITP AEELDFRVHI RSELMRLGLH
QVLQLRFLTT EDTFGVQLNV FDEQGEEDSY DLKGRLDDIR MEMEYPFILL NTVRDSNAEP
HFLSILQHLL LVRNDYEARP QYYKLIEECI SQIVLHKNGA DPDFKCRHLQ IEIEGLIDQM
IDKTKVEKSE AKAAELEKKL DSELTARHEL QVEMKKMESD FEQKLQDLQG EKDALHSEKQ
QIATEKQDLE AEVSQLTGEV AKLTKELEDA KKEMASLSAA AITVPPSVPS RAPVPPAPPL
PGDSGTIIPP PPAPGDSTAI SPPPPLSGDA TISPPPPLPE GVGIPSPSSL PGGTAIPPPP
PLPGSAGIPP PPPPLPGEAG MPPPPPPLPG GPGIPPPPPF PGGPGIPPPP PGMGMPPPPP
FGFGVPAAPV LPFGLTPKKL YKPEVQLRRP NWSKLVAEDL SQDCFWTKVK EDRFENNELF
AKLTLTFSAQ TKTKKDQEGG EEKKSVQKKK VKELKVLDSK TAQNLSIFLG SFRMPYQDIK
NVILEVNEAV LTESMIQNLI KQMPEPEQLK MLSELKDEYD DLAESEQFGV VMGTVPRLRP
RLNAILFKLQ FSEQVENIKP EIVSVTAACE ELRKSESFSS LLEITLLVGN YMNAGSRNAG
AFGFNISFLC KLRDTKSTDQ KMTLLHFLAE LCENDYPDVL KFPDELAHVE KASRVSAENL
QKNLDQMKKQ ISDVERDVQN FPAATDEKDK FVEKMTISSL ERRDFVKDAQ EQYNKLRMMH
SNMETLYKEL GEYFLFDPKK LSVEEFFMDL HNFRNMFLQA VKENQKRRET EEKMRRAKLA
KEKAEKERLE KQQKREQLID MNAEGDETGV MDSLLEALQS GAAFRRKRGP RQANRKAGCA
VTSLLASELT KDDAMAAVPA KVSKNSETFP TILEEAKELV GRAS
//
