ID G3QJN5_GORGO Unreviewed; 421 AA.
AC G3QJN5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Ankyrin repeat and SOCS box containing 6 {ECO:0000313|Ensembl:ENSGGOP00000002634.3};
GN Name=ASB6 {ECO:0000313|Ensembl:ENSGGOP00000002634.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002634.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002634.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002634.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000002634.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; CABD030067030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004048766.1; XM_004048718.2.
DR AlphaFoldDB; G3QJN5; -.
DR STRING; 9593.ENSGGOP00000002634; -.
DR Ensembl; ENSGGOT00000002688.3; ENSGGOP00000002634.3; ENSGGOG00000002672.3.
DR GeneID; 101142910; -.
DR KEGG; ggo:101142910; -.
DR CTD; 140459; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00390000006784; -.
DR HOGENOM; CLU_000134_52_2_1; -.
DR InParanoid; G3QJN5; -.
DR OMA; HLCRVHI; -.
DR OrthoDB; 5352456at2759; -.
DR TreeFam; TF330837; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000002672; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03725; SOCS_ASB6; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037327; ASB6_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24132; ANKYRIN REPEAT AND SOCS BOX PROTEIN 6; 1.
DR PANTHER; PTHR24132:SF24; ANKYRIN REPEAT AND SOCS BOX PROTEIN 6; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT REPEAT 102..134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 360..415
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 421 AA; 47122 MW; 06A05A9C1FC25286 CRC64;
MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL VLTELLDRKA
HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE
LLVHHGADVN RRDRIHESSP LDLASEEPER LPCLQRLLDL GADVNAADKH GKTALLHALA
SSDGVQIHNT ENIRLLLEGG ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMINRFCF
QVTRLLLAHG ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
HIIFERLCSH PGCTEDESHA DLLRKAETVL DLMVTNSQKL QLPENFDIHP VGSLAEKIQA
LHFSLRQLES YPPPLKHLCR VAIRLYLQPW PVDVKVKALP LPDRLKWYLL SEHSGSVEDD
I
//
