ID G3QNV2_GORGO Unreviewed; 1155 AA.
AC G3QNV2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=ATP-dependent RNA helicase DHX30 {ECO:0000256|ARBA:ARBA00039388};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 30 {ECO:0000256|ARBA:ARBA00042917};
GN Name=DHX30 {ECO:0000313|Ensembl:ENSGGOP00000004230.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004230.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000004230.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000004230.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000004230.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000256|ARBA:ARBA00004436}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; CABD030021154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004034100.1; XM_004034052.2.
DR AlphaFoldDB; G3QNV2; -.
DR Ensembl; ENSGGOT00000004333.3; ENSGGOP00000004230.2; ENSGGOG00000004307.3.
DR eggNOG; KOG0920; Eukaryota.
DR GeneTree; ENSGT00940000158279; -.
DR HOGENOM; CLU_001832_1_2_1; -.
DR OrthoDB; 1095660at2759; -.
DR TreeFam; TF352030; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000004307; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17976; DEXHc_DHX30; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF229; ATP-DEPENDENT RNA HELICASE DHX30; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 405..573
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 615..788
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 111..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 129465 MW; 0CBBB2A77AB9FBE1 CRC64;
MAASRDLLKE FPQPKNLLNS VIGRALGISH AKDKLVYVHT NGPKKKKVTL HIKWPKSVEV
EGYGSKKIDA ERQAAAAACQ LFKGWGLLGP RNELFDAAKY RVLADRFGSP ADSWWRPEPT
MPPTSWRQLN PESIRPGGPG GLSRSLGREE EEDEEEELEE GTIDVTDFLS MTQQDSHAPL
RDSRGSSFEM TDDDSAIRAL TQFPLPKNLL AKVIQIATSS STAKNLMQFH TVGTKTKLST
LTLLWPCPMT FVAKGRRKAE AENKAAALAC KKLKSLGLVD RNNEPLTHAM YNLASLRELG
ETQRRPCTIQ VPEPILRKIE TFLNHYPVEN SWIAPELRLQ SDDILPLGKD SGPLSDPITG
KPYVPLLEAE EVRLSQSLLE LWRRRGPVWQ EAPQLPVDPH RDTILNAIEQ HPVVVISGDT
GCGKTTRIPQ LLLERYVTEG RGARCNVIIT QPRRISAVSV AQRVSHELGP SLRRNVGFQV
RLESKPPSRG GALLFCTVGI LLRKLQSNPS LEGVSHVIVD EVHERDVNTD FLLILLKGLQ
RLNPALRLVL MSATGDNERF SRYFGGCPVI KVPGFMYPVK EHYLEDILAK LGKHQYLHRH
RHHESEDECA LDLDLVTDLV LHIDARGEPG GILCFLPGWQ EIKGVQQRLQ EALGMHESKY
LILPVHSNIP MMDQKAIFQQ PPVGVRKIVL ATNIAETSIT INDIVHVVDS GLHKEERYDL
KTKVSCLETV WVSRANVIQR RGRAGRCQSG FAYHLFPRSR LEKMVPFQVP EILRTPLENL
VLQAKIHMPE KTAVEFLSKA VDSPNIKAVD EAVILLQEIG VLDQREYLTT LGQRLAHIST
DPRLAKAIVL AAIFRCLHPL LVVVSCLTRD PFSSSLQNRA EVDKVKALLS HDSGSDHLAF
VRAVAGWEEV LRWQDRSSRE NYLEENLLYA PSLRFIHGLI KQFSENIYEA FLVGKPSDCT
LASAQCNEYS EEEELVKGVL MAGLYPNLIQ VRQGKVTRQG KFKPNSVTYR TKSGNILLHK
STINREATRL RSRWLTYFMA VKSNGSVFVR DSSQVHPLAV LLLTDGDVHI RDDGRRATIS
LSDSDLLRLE GDSRTVRLLK ELRRALGRMV ERSLRSELAA LPPSVQEEHG QLLALLAELL
RGPCGSFDVR KTADD
//
