ID G3QQT2_GORGO Unreviewed; 960 AA.
AC G3QQT2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=EGF like, fibronectin type III and laminin G domains {ECO:0000313|Ensembl:ENSGGOP00000004956.2};
GN Name=EGFLAM {ECO:0000313|Ensembl:ENSGGOP00000004956.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004956.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000004956.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000004956.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000004956.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CABD030105494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QQT2; -.
DR STRING; 9593.ENSGGOP00000004956; -.
DR Ensembl; ENSGGOT00000005083.3; ENSGGOP00000004956.2; ENSGGOG00000005053.3.
DR eggNOG; KOG0613; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR GeneTree; ENSGT00940000158504; -.
DR HOGENOM; CLU_013380_0_0_1; -.
DR InParanoid; G3QQT2; -.
DR OMA; CGEGTIE; -.
DR TreeFam; TF326548; -.
DR Proteomes; UP000001519; Chromosome 17.
DR Bgee; ENSGGOG00000005053; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0098684; C:photoreceptor ribbon synapse; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF88; PIKACHURIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..960
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003451365"
FT DOMAIN 37..136
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 286..324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..507
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 508..545
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 552..731
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 727..763
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 778..957
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 295..312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 314..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 535..544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 753..762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 930..957
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 960 AA; 104760 MW; 51C6591D1CFA519C CRC64;
MDLIRGVLLR LLLLASSLGP GAVSLRAAIR KPGKVGPPLD IKLGALNCTA FSIQWKMPRH
PGSPILGYTV FYSEVGADKS LQEQLHSVPL SRDIPITEEV IGDLKPDTEY RVSIAAYSQA
GKGRLSSPRH VTTLSQESCL PPAAPQQPHV IVVSDSEVAL SWKPGASEGS APIQYYSVEF
IPEEAGSGRY GPRYITDMGA GEDDEGFEDD LDLDISFEEV KPLPATKGGN KKFLVESKKM
SISNPKTISR LIPPTSASLP MTTVAPQPIP VQRKGKNGVA IMSRLFDMPC DETLCSADSF
CVNDYTWGGS RCQCTLGKGG ESCSEDIVIQ YPQFFGHSYV TFEPLKNSYQ AFQITLEFRA
EAEDGLLLYC GENEHGRGDF MSLAIIRRSL QFRFNCGTGV AIIVSETKIK LGGWHTVMLY
RDGLNGLLQL NNGTPVTGQS QGQYSKITFR TPLYLGGAPS AYWLVRATGT NRGFQGCVQS
LAVNGRRIDM RPWPLGKALS GADVGECSSG ICDEASCING GTCTAIKADS YICLCPLGFK
GRHCEDAFTL TIPQFRESLR SYAATPWPLE PQHYLSFMEF EITFRPDSGD GVLLYSYDTG
SKDFLSINLA GDHVEFRFDC GSGTGVLRSE DPLTLGNWHE LHVSRTAKNG ILQVDKQKIV
EGMAEGGFTQ IKCNTDIFIG GVPNYDDVKK NSGVLKPFSG SIQKIILNDR TIHVKHDFTS
GVNVENAAHP CVRAPCAHGG SCRPRKEGYD CDCPLGFEGL HCQKECGNYC LNTIIEAIEI
PQFIGRSYLT YDNPDILKRV SGSRSNVFMR FKTTAKDGLL LWRGDSPMRP NSDFISLGLR
DGALVFSYNL GSGVASIMVN GSFNDGRWHR VKAVRDGQSG KITVDDYGAR TGKSPGMMRQ
LNINGALYVG GMKEIALHTN RQYMRGLVGC ISHFTLSTDY HISLVEDAVD GKNINTCGAK
//
