ID G3QS67_GORGO Unreviewed; 365 AA.
AC G3QS67;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=CD244 molecule {ECO:0000313|Ensembl:ENSGGOP00000005494.3};
GN Name=CD244 {ECO:0000313|Ensembl:ENSGGOP00000005494.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000005494.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000005494.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000005494.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000005494.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030006884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018892255.1; XM_019036710.1.
DR AlphaFoldDB; G3QS67; -.
DR STRING; 9593.ENSGGOP00000005494; -.
DR Ensembl; ENSGGOT00000005638.3; ENSGGOP00000005494.3; ENSGGOG00000005612.3.
DR GeneID; 101145866; -.
DR KEGG; ggo:101145866; -.
DR CTD; 51744; -.
DR eggNOG; ENOG502S7N7; Eukaryota.
DR GeneTree; ENSGT01030000234540; -.
DR HOGENOM; CLU_065827_0_0_1; -.
DR InParanoid; G3QS67; -.
DR OMA; VDIHGTH; -.
DR OrthoDB; 5363071at2759; -.
DR TreeFam; TF334964; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000005612; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042288; F:MHC class I protein binding; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0071663; P:positive regulation of granzyme B production; IEA:Ensembl.
DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR024303; NK_rcpt_2B4_Ig_dom.
DR PANTHER; PTHR12080:SF56; NATURAL KILLER CELL RECEPTOR 2B4; 1.
DR PANTHER; PTHR12080; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE; 1.
DR Pfam; PF11465; Receptor_2B4; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..365
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014174285"
FT TRANSMEM 222..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..210
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 317..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 41266 MW; 7F574D94DFC2AB6A CRC64;
MLGQEVTLVL LLLLKVYQGK GCQGSADHVV SISGVPLQLQ PNSIQTKVDN IAWKKLLPSQ
NEFHQILKWE NGSLPYNTSN DRFSFTVENL SLLIKAAQQQ DSGLYCLEVT SISGKVQTAK
FQVFVFDKVE KPRLRGQGKI LDRGRCQVAL SCLVSRDGNM TYAWYRGSKL IQTAGNLTFL
DEEVDINGTH TYTCNVSNPV SWESHTLNLT QDCQNAHQEF RFWPFLVIIV ILSTLFLGTL
ACFCVRRRKR KGKQSETSPK EFLTIYEDVK DLKTRRNQEQ EQTFPGAGST IYSMIQSQSS
APTSQEPAYT LYSLIQPSRK SGSRKRNHSP SFNSTIYEVI GKSQPKAQNP ARLSRKELEN
FDVYS
//
