ID G3QUX7_GORGO Unreviewed; 829 AA.
AC G3QUX7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|ARBA:ARBA00029538, ECO:0000256|PIRNR:PIRNR028921};
GN Name=VPS41 {ECO:0000313|Ensembl:ENSGGOP00000006538.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006538.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006538.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006538.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006538.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport
CC pathways. {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Early endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|PIRNR:PIRNR028921}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR EMBL; CABD030050843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030050850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QUX7; -.
DR STRING; 9593.ENSGGOP00000006538; -.
DR Ensembl; ENSGGOT00000006709.3; ENSGGOP00000006538.3; ENSGGOG00000006665.3.
DR eggNOG; KOG2066; Eukaryota.
DR GeneTree; ENSGT00390000000481; -.
DR HOGENOM; CLU_001285_2_2_1; -.
DR InParanoid; G3QUX7; -.
DR OMA; PQLVWQD; -.
DR TreeFam; TF300451; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000006665; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:Ensembl.
DR GO; GO:0071439; C:clathrin complex; IEA:Ensembl.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1902501; C:lysosomal HOPS complex; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:1902774; P:late endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR CDD; cd16690; RING-H2_Vps41; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR PIRSF; PIRSF028921; VPS41; 1.
DR SMART; SM00299; CLH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR028921};
KW Endosome {ECO:0000256|PIRNR:PIRNR028921};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR028921}; Lysosome {ECO:0000256|PIRNR:PIRNR028921};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transport {ECO:0000256|PIRNR:PIRNR028921};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 766..814
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 95915 MW; B09CB0062070FD3F CRC64;
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC MTVHDKFLAL
GTHYGKVYLL DVQGNITQKF DVVQVFGLYS GEEFQETFDC PIKIIAVHPH FVRSSCKQFV
TGGKKLLLFE RSWMNRWKSA VLHEGEGNIR SVKWRGHLIA WANNMGVKIF DIISKQRITN
VPRDDISLRP DMYPCSLCWK DNVTLIIGWG TSVKVCSVKE RHASEMRDLP SRYVEIVSQF
ETEFYISGLA PLCDQLVVLS YVKEISEKTE REYCARPRLD IIQPLSETCE EISSDALTVR
GFQENECRDY HLEYSEGESL FYIVSPRDVV VAKERDQDDH IDWLLEKKKY EEALMAAEIS
QKNIKRHKIL DIGLAYINHL VERGDYDIAA RKCQKILGKN AALWEYEVYK FKEIGQLKAI
SPYLPRGDPV LKPLIYEMIL HEFLESDYEG FATLIREWPG DLYNNSVIVQ AVRDHLKKDS
QNKTLLKTLA ELYTYDKNYG NALEIYLTLR HKDVFQLIHK HNLFSSIKDK IVLLMDFDSE
KAVDMLLDNE DKISIKKVVE ELEDRPELQH VYLHKLFKRD HHKGQRYHEK QISLYAEYDR
PNLLPFLRDS THCPLEKALE ICQQRNFVEE TVYLLSRMGN SRSALKMIME ELHDVDKAIE
FAKEQDDGEL WEDLILYSID KPPFITGLLN NIGTHVDPIL LIHRIKEGME IPNLRDSLVK
ILQDYNLQIL LREGCKKILV ADSLSLLKKM HRTQMKGVLV DEENICESCL SPILPSDAAK
PFSVVVFHCR HMFHKECLPM PSMNSAAQFC NICSAKNRGP GSAILEMKK
//
