ID G3QWT3_GORGO Unreviewed; 1302 AA.
AC G3QWT3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Apoptotic chromatin condensation inducer 1 {ECO:0000313|Ensembl:ENSGGOP00000007252.3};
GN Name=ACIN1 {ECO:0000313|Ensembl:ENSGGOP00000007252.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007252.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007252.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007252.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000007252.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030091880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004054990.1; XM_004054942.2.
DR STRING; 9593.ENSGGOP00000007252; -.
DR Ensembl; ENSGGOT00000007444.3; ENSGGOP00000007252.3; ENSGGOG00000007403.3.
DR GeneID; 101130589; -.
DR CTD; 22985; -.
DR eggNOG; KOG2416; Eukaryota.
DR GeneTree; ENSGT00710000106790; -.
DR HOGENOM; CLU_005840_0_0_1; -.
DR InParanoid; G3QWT3; -.
DR OMA; DYHKGIR; -.
DR OrthoDB; 1411884at2759; -.
DR TreeFam; TF320727; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000007403; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0061574; C:ASAP complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR CDD; cd12432; RRM_ACINU; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR034257; Acinus_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR032552; RSB_motif.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR46589; APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS; 1.
DR PANTHER; PTHR46589:SF1; APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS; 1.
DR Pfam; PF16294; RSB_motif; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 72..106
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..251
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1091
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1153
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1302 AA; 147605 MW; B4A795BE899A72F7 CRC64;
MWRRKYPRTS GGTRGVLSGN RGVEYGSGRG HLGTFEGRWR KLPKMPEAVG TDPSTSRKMA
ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK RLKGALMLEN LQKHSTPHAA
FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ RLEREAREAA ELEGKSSSIS EEKGDSDDEK
PRKGERRSSR VRQARAAKLS EGSQPAEEEE DQETPSRNLR VRADRNLKTE EEEEEEEEEE
DDEEEEDDDE GQKSREAPIL KEFKEEGEEM PRVKPEEMMD ERPKTRSQEQ EVLERGGRFT
RSQEEARKTH LARQQQEKEM KTTSPLEEEE REIKSSQGLK EKSKSPSPPR LTEDQKKASL
VALPEQTASE EETPPPLLTK EASSPPPHPQ LHSEEEIEPM EGPAPPVLIQ LSPPNADADT
RELLVSQHTV QLVGSLSPLS SPSDTKAESP AEKVPEESVL PLVQKSTLAD YSAQKDLEPE
SDRSAQPLPL KIEELALAKG ITEECLKQPS LEQKEGRRAS HTLLPSHRLK QSADSSSSRS
SSSSSSSSRS RSRSPDSSGS RSHSPLRSKQ RDVAQARTHA NPRGRPKMGS RSTSESRSRS
RSRSRSRSAS SNSRKSLSPG VSRDSSTSYT ETKDPSSGQE VATPPVPQLQ VCEPKERTST
SSSSVQARRL SQPESAEKHV TQRLQPERGS PKKCEAEEAE PPAATQPQTS ETQTSHLPES
ERIHHTVEEK EEVTMDTSEN RPENDVPEPP MPIADQVSND DRPEGSVEDE EKKESSLPKS
FKRKISVVSA TKGVPAGNSD TEGGQPGRKR RWGASTATTQ KKPSISITTE SLKSLIPDIK
PLAGQEAVVD LHADDSRISE DETERNGDDG THDKGLKICR TVTQVVPAEG QENGQREEEE
EEKEPEAEPP VPPQVSVEVA LPPPAEHEVK KVTLGDTLTR RSISQQKSGV SITIDDPVRT
AQVPSPPRGK ISNIVHISNL VRPFTLGQLK ELLGRTGTLV EEAFWIDKIK SHCFVTYSTV
EEAVATRTAL HGVKWPQSNP KFLCADYAEQ DELDYHRGLL VERPSETKTE EQGIPRPLHP
PPPPPVQPPQ HPRAEQREQE RAVREQWAER EREMERRERT RSEREWDRDK VREGPRSRSR
SRDRRRKERA KSKEKKSEKK EKAQEEPPAK LLDDLFRKTK AAPCIYWLPL TDSQIVQKEA
ERAERAKERE KRRKEQEEEE QKEREKEAER ERNRQLEREK RREHSRERDR ERERERERDR
GDRDRDRERD RERGRERDRR DTKRHSRSRS RSTPVRDRGG RR
//
