ID G3R0S8_GORGO Unreviewed; 815 AA.
AC G3R0S8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=RAS p21 protein activator 3 {ECO:0000313|Ensembl:ENSGGOP00000008774.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008774.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000008774.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000008774.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000008774.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030091005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R0S8; -.
DR Ensembl; ENSGGOT00000009013.3; ENSGGOP00000008774.3; ENSGGOG00000008967.3.
DR GeneTree; ENSGT00940000157953; -.
DR HOGENOM; CLU_008096_1_1_1; -.
DR OMA; CKEEYMA; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000008967; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13371; PH_GAP1_mammal-like; 1.
DR CDD; cd05134; RasGAP_RASA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037774; RASA3_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR PRINTS; PR00402; TECBTKDOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..93
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 104..244
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 311..505
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 557..658
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 815 AA; 93629 MW; 3E59DE393B0979D5 CRC64;
EAKNLPSYPG PSKMRDCYCT VNLDQEEVFR TKIVEKSLCP FYGEDFYCEI PRSFRHLSFY
IFDRDVFRRD SIIGKVAIQK EDLQKYHNRD TWFQLQHVDA DSEVQGKVHL ELRLSEVITD
TGVVCHKLAT RIVECQGLPI VNGQCDPYAT VTLAGPFRSE AKKTKVKRKT NNPQFDEVFY
FEVTRPCSYS KKSHFDFEEE DVDKLEIRVD LWNASNLKFG DEFLGELRIP LKVLRQSSSY
EAWYFLQPRD NGSKSLKPDD LGSLRLNVVY TEDHVFSSDY YSPLRDLLLK SADVEPVSAS
AAHILGEVCR EKQEAAVPLV RLFLHYGRVV PFISAIASAE VKRTQDPNTI FRGNSLASKC
IDETMKLAGM HYLHVTLKPA IEEICQSHKP CEIDPVKLKD GENLENNMEN LRQYVDRVFH
AITESGVSCP TVMCDIFFSL REAAAKRFQD DPDVRYTAVS SFIFLRFFAP AILSPNLFQL
TPHHTDPQTS RTLTLISKTV QTLGSLSKSK SASFKESYMA TFYEFFNEQK YADAVKNFLD
LISSSGRRDP KSVEQPIMLK EGFMIKRAQG RKRFGMKNFK KRWFRLTNHE FTYHKSKGDQ
PLYSIPIENI LAVEKLEEES FKMKNMFQVI QPERALYIQA NNCVEAKDWI DILTKVSQCN
QKRLTVYHPS AYLSGHWLCC RAPSDSAPGC SPCTGGLPAN IQLDIDGDRE TERIYSLFNL
YMSKLEKMQE ACGSKSVYDG PEQEEYSTFV IDDPQETYKT LKQVIAGVGA LEQEHAQYKR
DKFKKTKYGS QEHPIGDKSF QNYIRQQSET STHSI
//
