ID G3R579_GORGO Unreviewed; 185 AA.
AC G3R579;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Calcium and integrin binding family member 4 {ECO:0000313|Ensembl:ENSGGOP00000010449.3};
GN Name=CIB4 {ECO:0000313|Ensembl:ENSGGOP00000010449.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010449.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010449.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010449.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010449.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030013758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030013759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004029015.1; XM_004028966.2.
DR AlphaFoldDB; G3R579; -.
DR STRING; 9593.ENSGGOP00000010449; -.
DR Ensembl; ENSGGOT00000010756.3; ENSGGOP00000010449.3; ENSGGOG00000010718.3.
DR GeneID; 101129840; -.
DR KEGG; ggo:101129840; -.
DR CTD; 130106; -.
DR eggNOG; KOG0034; Eukaryota.
DR GeneTree; ENSGT00940000161840; -.
DR HOGENOM; CLU_061288_6_2_1; -.
DR InParanoid; G3R579; -.
DR OMA; CKVFSHN; -.
DR OrthoDB; 5472814at2759; -.
DR TreeFam; TF313865; -.
DR Proteomes; UP000001519; Chromosome 2A.
DR Bgee; ENSGGOG00000010718; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR45791; CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2; 1.
DR PANTHER; PTHR45791:SF4; CALCIUM AND INTEGRIN-BINDING FAMILY MEMBER 4; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 97..132
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 185 AA; 21713 MW; E0DB910464E221FF CRC64;
MGQCLRYQMH WEDLEEYQAL TFLTRNEILC IHDTFLKLCP PGKYYKEATL TMDQVSSLPA
LRVNPFRDRI CRVFSHKGVF SFEDVLGMAS VFSEQACPSL KIEYAFRIYD FNENGFIDEE
DLQRIILRLL NSDDMSEDLL MDLTNHVLSE SDLDNDNMLS FSEFEHAMAK SPDFMNSFRI
HFWGC
//
