ID G3R5L5_GORGO Unreviewed; 1478 AA.
AC G3R5L5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Calmodulin regulated spectrin associated protein family member 2 {ECO:0000313|Ensembl:ENSGGOP00000010594.3};
GN Name=CAMSAP2 {ECO:0000313|Ensembl:ENSGGOP00000010594.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010594.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010594.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010594.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010594.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR EMBL; CABD030008253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018884051.1; XM_019028506.1.
DR Ensembl; ENSGGOT00000010909.3; ENSGGOP00000010594.3; ENSGGOG00000010861.3.
DR GeneID; 101149448; -.
DR CTD; 23271; -.
DR eggNOG; KOG3654; Eukaryota.
DR GeneTree; ENSGT00950000182975; -.
DR HOGENOM; CLU_004833_1_0_1; -.
DR OrthoDB; 2918432at2759; -.
DR TreeFam; TF315529; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000010861; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF1; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 211..324
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1338..1472
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 364..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 750..777
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 877..914
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 659..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1478 AA; 166852 MW; E1E604969D091909 CRC64;
MGDAADPREM RKTFIVPAIK PFDHYDFSRA KIACNLAWLV AKAFGTENVP EELREPFYTD
QYDQEHIKPP VVNLLLSAEL YCRAGSLILK SDAAKPLLGH DAVIQALAQK GLYVTDQEKL
VTERDLHKKP IQMSAHLAMI DTLMMAYTVE MVSIEKVIAC AQQYSAFFQA TDLPYDIEDA
VMYWINKVNE HLKDIMEQEQ KLKEHHTVEA PGGQKARYRK EQTLLKQLPC IPLVENLLKD
GTDGCALAAL IHFYCPDVVR LEDICLKETM SLADSLYNLQ LIQEFCQEYL NQCCHFTLED
MLYAASSIKS NYLVFMAELF WWFEVVKPSF VQPRVVRPQG AEPVKDMPSI PVLNAAKRNV
LDSSSDFPSS GEGATFTQSH HHLPSRYSRP QAHSSASGGI RRSSSMSYVD GFIGTWPKEK
RSSVHGVSFD ISFDKEDSVQ RSTPNRGITR SISNEGLTLN NSRVSKHIRK NLSFKPINGE
EEAESIEEEL NIDSHSDLKS YVPLNTNELN SNENIHYKLP NGALQNRILL DEFGNQIETP
SIEEALQIIH DTEKSPHTPQ PDQIANGFFL HSQEMSILNS NIKLNQSSPD NVTDTKGALS
PITDNTEVDT GIHVPSEDIP ETMDEDSSLR DYTVSLDSDM DDASKFLQDY DIRTGNTREA
LSPCPSTVST KSQPGSSASS SSGVKMTSFA EQKFRKLNHT DGKSSGSSSQ KTTPEGSELN
IPHVVAWAQI PEETGLPQGR DTTQLLASEM VHLRMKLEEK RRAIEAQKKK MEAAFTKQRQ
KMGRTAFLTV VKKKGDGISP LREEAAGAED EKVYTDRAKE KESQKTDGQR SKSLADIKES
MENPQAKWLK SPTTPVDPEK QWNLASPSEE TLNEGEILEY TKSIEKLNSS LHFLQQEMQR
LSLQQEMLMQ MREQQSWVIS PPQPSPQKQI RDFKPSKQAG LSSAIAPFSS DSPRPTHPSP
QSSNRKSASF SVKNQRTPRP NELKITPLNR TLTPPRSVDS LPRLRRFSPS QVPIQTRSFV
CFGDDGEPQL KESKPKEEVK KEELESKGTL EQRGHNPEEK EIKPFESTVS EVLSLPVTET
VCLTPNEDQL NQPTEPPPKP VFPPTAPKNV NLIEVSLSDL KPPEKADVPV EKYDGESDKE
QFDDDQKVCC GFFFKDDQKA ENDMAMKRAA LLEKRLRREK ETQLRKQQLE AEMEHKKEET
RRKTEEERQK KEDERARREF IRQEYMRRKQ LKLMEDMDTV IKPRPQVVKQ KKQRPKSIHR
DHIESPKTPI KGPPVSSLSL ASLNTGDNES VHSGKRTPRS ESVEGFLSPS RCGSRNGEKD
WENASTTSSV ASGTEYTGPK LYKEPSAKSN KHIIQNALAH CCLAGKVNEG QKKKILEEME
KSDANNFLIL FRDSGCQFRS LYTYCPETEE INKLTGIGPK SITKKMIEGL YKYNSDRKQF
SHIPAKTLSA SVDAITIHSH LWQTKRPVTP KKLLPTKA
//
