ID G3RDZ2_GORGO Unreviewed; 531 AA.
AC G3RDZ2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Pleckstrin homology and RhoGEF domain containing G7 {ECO:0008006|Google:ProtNLM};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013756.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013756.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013756.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013756.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030085993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RDZ2; -.
DR STRING; 9593.ENSGGOP00000013756; -.
DR Ensembl; ENSGGOT00000014150.3; ENSGGOP00000013756.3; ENSGGOG00000014096.3.
DR eggNOG; KOG3521; Eukaryota.
DR GeneTree; ENSGT00510000046843; -.
DR HOGENOM; CLU_030833_0_0_1; -.
DR InParanoid; G3RDZ2; -.
DR OMA; RFFIPEY; -.
DR TreeFam; TF316247; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000014096; Expressed in adult mammalian kidney.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd13245; PH_PLEKHG7; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR PANTHER; PTHR13217:SF6; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 128..328
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 375..508
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 531 AA; 61634 MW; D3E78124A8C5AD5D CRC64;
MGLVPSDLTS LGQRNSGFYE HRRSSVVLNL PGLEVFPGDL LVSDGAADYL CHPLLLLNSE
SKKPRWPFSK RGVGKDKHKH ISDLENCLSS VKITSFRGYD FYGLKDKTWD EVLETHHKLP
TDQLDLKKQQ EAVWELFTSE CTYFLDHLLV LKMIFMNTLK YLQTHEYLLD VDLWRLFANL
EELTQTSLGF VNSLFGIIKD CVDASEISSS LDFISVLTKY FRGSLCQSHQ TYCLNYSAAI
FYLESLRQRD DFGIYLKWCE QNEQCRRLHL PELLVAPLQR LTRYPLLLKN IWKRSMDSAE
KIMIYSIKEK VEKSIRDLEG KVKWLDNFQK FRYLQEIIVW PPLWDRDKRF FIPECLKHIF
KEHTAENILS PTNRHLLYEG KLTLAESTRF LDVYLFLFND FLLVTKTKRN KKKLGGSDPG
LMCPSLTPEL QAVIKEGGSC TVLDQPIPLD RLVVKSIEPL HVSVFGLRNA FLIQHENRYR
QCIAAFLLQA QTENIKKTWM AQITTAISCF TKSQETKKIS LFTLPAESSE I
//
