ID G3REG6_GORGO Unreviewed; 387 AA.
AC G3REG6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Lysophosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00015438};
DE EC=3.1.1.23 {ECO:0000256|ARBA:ARBA00013254};
DE AltName: Full=2-arachidonoylglycerol hydrolase ABHD12 {ECO:0000256|ARBA:ARBA00033386};
DE AltName: Full=Abhydrolase domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032497};
DE AltName: Full=Monoacylglycerol lipase ABHD12 {ECO:0000256|ARBA:ARBA00030575};
DE AltName: Full=Oxidized phosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00030502};
GN Name=ABHD12 {ECO:0000313|Ensembl:ENSGGOP00000013952.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013952.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013952.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013952.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013952.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.;
CC EC=3.1.1.23; Evidence={ECO:0000256|ARBA:ARBA00001613};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the serine esterase family.
CC {ECO:0000256|ARBA:ARBA00006584}.
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DR EMBL; CABD030116003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030116011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3REG6; -.
DR STRING; 9593.ENSGGOP00000013952; -.
DR ESTHER; gorgo-g3reg6; ABHD12-PHARC.
DR Ensembl; ENSGGOT00000014355.3; ENSGGOP00000013952.3; ENSGGOG00000014299.3.
DR eggNOG; KOG1552; Eukaryota.
DR GeneTree; ENSGT00940000160517; -.
DR InParanoid; G3REG6; -.
DR OMA; VEFHRFE; -.
DR TreeFam; TF315122; -.
DR Proteomes; UP000001519; Chromosome 20.
DR Bgee; ENSGGOG00000014299; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:Ensembl.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0052651; P:monoacylglycerol catabolic process; IBA:GO_Central.
DR GO; GO:0006660; P:phosphatidylserine catabolic process; IBA:GO_Central.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF61; LYSOPHOSPHATIDYLSERINE LIPASE ABHD12; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..257
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 18..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 44017 MW; 15CF7C3AAE9531F3 CRC64;
MRKRTEPVAL EHERCGRQRG RRQTLRALGP TRTSSSCSAS GPTPSARAGG VWLRLRKILF
CVLGLYIAIP FLIKLCPGIQ AKLIFLNFVR VPYFIDLKKP QDQGLNHTCN YYLQPEEDVT
IGVWHTVPAV WWKNAQGKDQ MWYEDALASS HPIILYLHGN AGTRGGDHRV ELYKVLSSLG
YHVVTFDYRG WGDSVGTPSE RGMTYDALHV FDWIKARSGD NPVYIWGHSL GTGVATNLVR
RLCERETPPD ALILESPFTN IREEAKSHPF SVIYRYFPGF DWFFLDPITS SGIKFANDEN
VKHISCPLLI LHAEDDPVVP FQLGRKLYSI AAPARSFRDF KVQFVPFHSD LGYRHKYIYK
SPELPRILRL QQGPGSSPDP SMWSELV
//
