ID G3RIQ0_GORGO Unreviewed; 1192 AA.
AC G3RIQ0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G4 {ECO:0000313|Ensembl:ENSGGOP00000015562.2};
GN Name=PLEKHG4 {ECO:0000313|Ensembl:ENSGGOP00000015562.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000015562.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000015562.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000015562.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000015562.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030101643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018868336.1; XM_019012791.1.
DR AlphaFoldDB; G3RIQ0; -.
DR Ensembl; ENSGGOT00000016008.3; ENSGGOP00000015562.2; ENSGGOG00000015950.3.
DR eggNOG; KOG0689; Eukaryota.
DR GeneTree; ENSGT00940000158845; -.
DR HOGENOM; CLU_001356_3_0_1; -.
DR TreeFam; TF334329; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000015950; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 733..909
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 921..1028
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 130934 MW; 053220359292C41D CRC64;
MERPLENGDE SPDSQGHATD WRFAVCSFRD AWEEEEPASQ MHIKDPGPPR PPAGATQDEE
LQGSPLSRKL QLPPAADESG DAQRGTVESS SVLSEGPGPS GVESLLCPMS SHLSLAQGES
DTPGVGLVGD PGPSRAMPSG LSPGALDSDP VGLGDPLSEI SSKLLEAAPS GSGLPKPADC
LLAQDLCWEL LASGMATLPG TRDVQGRAVL LLCAHSPAWL QSECSSQELI RLLLYLRSIP
RPEVQALGLT VLIDARICAP SSSLFSGLSQ LQEAAPGAVY QVLLVGSMLL KEVPSGLQLE
QLPSQSLLTH IPTAGLPTSL GGGLPYCHQA WLDFRRRLEA LLQNCQAACA LLQGAIESVK
AVPQPMEPGE VGQLLQQTEV LMQQVLDSPR LAWLQCQGGR ELTWLKQEVP EVTLSPDYRT
AMDKADELYD RVDGLLHKLT LQSNQRIQAL ELVQTLEARE SGLHQIEVWL QQVGWPALEE
PGEPSLDMLL QAQGSFRELY QVAQEQVRQG EKFLQPLTGW EAAELGPPGA RFLALRAQLT
EFSRALAQRC QRLADAERLF QLFREALTWA EEGQRVLAEL EQERPGVVLQ QLQLHWTRHP
DLPPAHFRKM WALATGLGSE AIRQECRWAW ARCQDTWLAL DQKLEASLKL PPVGSTASLC
VSQVPAAPAH PPLRKAYSFD RNLGQSLSEP ARHCHHAAAI AACRRPETGG GALPQASPTV
PPPGSSDPRS LNRLQLVLAE MVATEREYVR ALGYTMENYF PELDRPDVPQ GLRGQRAHLF
GNLEKLRDFH CHFFLRELEA CTRHPPRVAY AFLRHRVQFG MYALYSKNKP RSDALMSSYG
HTFFKDKQQA LGDHLDLASY LLKPIQRMGK YALLLQELAR ACGGPTQELS ALREAQSLVH
FQLRHGNDLL AMDAIQGCDV NLKEQGQLVR QDEFVVRTGR HKSVRRIFLF EELLLFSKPR
HGPTGVDTFA YKRSFKMADL GLTECCGNSN LRFEIWFRRR KARDTFVLQA SSLAIKQAWT
ADISHLLWRQ AVHNKEVRMA EMVSMGVGNK AFRDIAPSEE AINDRTVNYV LKCREVRSRA
SIAVAPFDHD SLYLGASNSL PGDPASCSVL GSLNLHLYRD PALLGLRCPL YPNFPEEAAL
EAEAELGGQP SLTAEDSEVS SQCPSASGSS GSDSSCVSGQ ALGRGLEDLP YV
//
