ID G3RTG1_GORGO Unreviewed; 507 AA.
AC G3RTG1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=P3R3URF-PIK3R3 readthrough {ECO:0000313|Ensembl:ENSGGOP00000019086.1};
GN Name=PIK3R3 {ECO:0000313|Ensembl:ENSGGOP00000019086.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000019086.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000019086.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000019086.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000019086.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030002943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030002952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018873278.1; XM_019017733.1.
DR AlphaFoldDB; G3RTG1; -.
DR STRING; 9593.ENSGGOP00000019086; -.
DR Ensembl; ENSGGOT00000027898.2; ENSGGOP00000019086.1; ENSGGOG00000010206.3.
DR eggNOG; KOG4637; Eukaryota.
DR GeneTree; ENSGT00940000156259; -.
DR InParanoid; G3RTG1; -.
DR TreeFam; TF102033; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000010206; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd12925; iSH2_PIK3R3; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 111..206
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 404..498
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 227..254
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 292..340
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 507 AA; 59408 MW; D5ED1AA984465CC0 CRC64;
MGPSRLVRGP RPQGMRSPYR RPGMGWPRPR FPRMFKCSRR RYQQGLRGRT ASSAAINPAT
RAMGINNTHT DTTIVWIFPP QALPPKPPKP MTSAVPNGMK DSSVSLQDAE WYWGDISREE
VNDKLRDMPD GTFLVRDAST KMQGDYTLTL RKGGNNKLIK IYHRDGKYGF SDPLTFNSVV
ELINHYHHES LAQYNPKLDV KLMYPVSRYQ QDQLVKEDNI DAVGKKLQEY HSQYQEKSKE
YDRLYEEYTR TSQEIQMKRT AIEAFNETIK IFEEQCHTQE QHSKEYIERF RREGNEKEIE
RIMMNYDKLK SRLGEIHDSK MRLEQDLKKQ ALDNREIDKK MNSIKPDLIQ LRKIRDQHLV
WLNHKGVRQK RLNVWLGIKN EDADENYFIN EEDENLPHYD EKTWFVEDIN RVQAEDLLYG
KPDGAFLIRE SSKKGCYACS VVADGEVKHC VIYSTARGYG FAEPYNLYSS LKELVLHYQQ
TSLVQHNDSL NVRLAYPVHA QMPSLCR
//
