ID G3S4W5_GORGO Unreviewed; 958 AA.
AC G3S4W5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=SLIT and NTRK like family member 5 {ECO:0000313|Ensembl:ENSGGOP00000023118.1};
GN Name=SLITRK5 {ECO:0000313|Ensembl:ENSGGOP00000023118.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000023118.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000023118.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000023118.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000023118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR EMBL; CABD030090214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004054686.1; XM_004054638.2.
DR RefSeq; XP_018895509.1; XM_019039964.1.
DR AlphaFoldDB; G3S4W5; -.
DR STRING; 9593.ENSGGOP00000023118; -.
DR Ensembl; ENSGGOT00000009622.3; ENSGGOP00000023118.1; ENSGGOG00000009585.3.
DR GeneID; 101125170; -.
DR KEGG; ggo:101125170; -.
DR CTD; 26050; -.
DR eggNOG; ENOG502QUVV; Eukaryota.
DR GeneTree; ENSGT00940000158453; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; G3S4W5; -.
DR OMA; LTGEMFF; -.
DR OrthoDB; 5309131at2759; -.
DR TreeFam; TF326378; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000009585; Expressed in prefrontal cortex and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IBA:GO_Central.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR45773:SF5; SLIT AND NTRK-LIKE PROTEIN 5; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 665..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..285
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 563..613
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 317..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..812
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 107484 MW; 7D7002A077D03F26 CRC64;
MHTCCPPVTL EQDLHRKMHS WILQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI
LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE FVNYTGASIL HLGSNVIQDI
ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHLLQ
VLILNDNLLS SLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS
CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL
STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP
SIAYQTKSPV PLECPTACTC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY
IAVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLTNLR RLYLNGNRIE RLSPELFYGL
QSLQYLFLQY NLIREIQSGT FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF
TSLPVSGVLD QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKMGVLVDEV ICKAPKKFAE
TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA GLGAGGGASS
VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG
GGTGGHPHAH VHHRGPALPK VKTPAGHVYE YIPHPLGHMC KNPIYRSREG NSVEDYKDLH
ELKVTYSSNH HLQQQQQPPP PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP
REDLLSPVQD ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ
YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE KQTTFSQF
//
