ID G3S894_GORGO Unreviewed; 558 AA.
AC G3S894;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Polypyrimidine tract binding protein 3 {ECO:0000313|Ensembl:ENSGGOP00000024307.1};
GN Name=PTBP3 {ECO:0000313|Ensembl:ENSGGOP00000024307.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024307.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024307.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024307.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000024307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030065900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004048496.2; XM_004048448.2.
DR AlphaFoldDB; G3S894; -.
DR SMR; G3S894; -.
DR STRING; 9593.ENSGGOP00000024307; -.
DR Ensembl; ENSGGOT00000023212.2; ENSGGOP00000024307.1; ENSGGOG00000001755.3.
DR GeneID; 101150016; -.
DR KEGG; ggo:101150016; -.
DR CTD; 9991; -.
DR eggNOG; KOG1190; Eukaryota.
DR GeneTree; ENSGT01050000244924; -.
DR InParanoid; G3S894; -.
DR OMA; NAHYARM; -.
DR OrthoDB; 4825346at2759; -.
DR TreeFam; TF319824; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000001755; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0033119; P:negative regulation of RNA splicing; IEA:Ensembl.
DR GO; GO:0045595; P:regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR CDD; cd12779; RRM1_ROD1; 1.
DR CDD; cd12693; RRM2_PTBP1_like; 1.
DR CDD; cd12703; RRM4_ROD1; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR033110; PTBP3_RRM4.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034326; ROD1_RRM1.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF17; POLYPYRIMIDINE TRACT-BINDING PROTEIN 3; 1.
DR Pfam; PF13893; RRM_5; 2.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 65..149
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 188..264
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 364..438
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 481..556
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 32..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 60417 MW; D20E5BA201A6CA84 CRC64;
MDASPSPFSL PKKLNELSAR RGSDELLSSG IINGPFTMNS STPSTANGND SKKFKRDRPP
CSPSRVLHLR KIPCDVTEAE IISLGLPFGK VTNLLMLKGK SQAFLEMASE EAAVTMVNYY
TPITPHLRSQ PVYIQYSNHR ELKTDNLPNQ ARAQAALQAV SAVQSGSLAL SGGPSNEGTV
LPGQSPVLRI IIENLFYPVT LEVLHQIFSK FGTVLKIITF TKNNQFQALL QYADPVNAHY
AKMALDGQNI YNACCTLRID FSKLTSLNVK YNNDKSRDFT RLDLPTGDGQ PSLEPPMAAA
FGAPGIISSP YAGAAGFAPA IGFPQATGLS VPAVPGALGP LTITSSAVTG RMAIPGASGI
PGNSVLLVTN LNPDLITPHG LFILFGVYGD VHRVKIMFNK KENALVQMAD ANQAQLAMNH
LSGQRLYGKV LRATLSKHQA VQLPREGQED QGLTKDFSNS PLHRFKKPGS KNFQNIFPPS
ATLHLSNIPP SVTVDDLKNL FIEAGCSVKA FKFFQKDRKM ALIQLGSVEE AIQALIELHN
HDLGENHHLR VSFSKSTI
//
