ID G3S999_GORGO Unreviewed; 1077 AA.
AC G3S999;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Phosphorylase b kinase regulatory subunit {ECO:0000256|RuleBase:RU364123};
GN Name=PHKB {ECO:0000313|Ensembl:ENSGGOP00000024664.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024664.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024664.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024664.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000024664.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of
CC serine in certain substrates, including troponin I.
CC {ECO:0000256|RuleBase:RU364123}.
CC -!- PATHWAY: Glycan biosynthesis; glycogen metabolism.
CC {ECO:0000256|ARBA:ARBA00005131, ECO:0000256|RuleBase:RU364123}.
CC -!- SUBUNIT: Hexadecamer of 4 heterotetramers, each composed of alpha,
CC beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB)
CC are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic
CC subunit, and delta is calmodulin. {ECO:0000256|ARBA:ARBA00025890,
CC ECO:0000256|RuleBase:RU364123}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342,
CC ECO:0000256|RuleBase:RU364123}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342,
CC ECO:0000256|RuleBase:RU364123}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the phosphorylase b kinase regulatory chain
CC family. {ECO:0000256|ARBA:ARBA00007128, ECO:0000256|RuleBase:RU364123}.
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DR EMBL; CABD030100915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030100924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3S999; -.
DR Ensembl; ENSGGOT00000023274.2; ENSGGOP00000024664.2; ENSGGOG00000003010.3.
DR GeneTree; ENSGT00950000183118; -.
DR HOGENOM; CLU_004177_0_1_1; -.
DR UniPathway; UPA00163; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000003010; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR011613; GH15-like.
DR InterPro; IPR045583; KPBA/B_C.
DR InterPro; IPR008734; PHK_A/B_su.
DR PANTHER; PTHR10749; PHOSPHORYLASE B KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10749:SF8; PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA; 1.
DR Pfam; PF00723; Glyco_hydro_15; 1.
DR Pfam; PF19292; KPBB_C; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860,
KW ECO:0000256|RuleBase:RU364123};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU364123};
KW Cell membrane {ECO:0000256|RuleBase:RU364123};
KW Glycogen metabolism {ECO:0000256|ARBA:ARBA00022600,
KW ECO:0000256|RuleBase:RU364123};
KW Lipoprotein {ECO:0000256|RuleBase:RU364123};
KW Membrane {ECO:0000256|RuleBase:RU364123};
KW Prenylation {ECO:0000256|RuleBase:RU364123};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 33..862
FT /note="GH15-like"
FT /evidence="ECO:0000259|Pfam:PF00723"
FT DOMAIN 903..1061
FT /note="Phosphorylase b kinase regulatory subunit alpha/beta
FT C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19292"
FT REGION 672..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 123230 MW; 461F025069526F35 CRC64;
WSRSPDLVIR SVYEPLKSIN LPRPDNETLW DKLDHYYRIV KSTLLLYQSP TTGLFPTKTC
GGDQKAKIQD SLYCAAGTWA LALAYRRIDD DKGRTHELEH SAIKCMRGIL YCYMRQADKV
QQFKQDPRPT TCLHSVFNVH TGDELLSYEE YGHLQINAVS LYLLYLVEMI SSGLQIIYNT
DEVSFIQNLV FCVERVYRVP DFGVWERGSK YNNGSTELHS SSVGLAKAAL EAINGFNLFG
NQGCSWSVIF VDLDAHNRNR QTLCSLLPRE SRSHNTDAAL LPCISYPAFA LDDEVLFSQT
LDKVVRKLKG KYGFKRFLRD GYRTSLEDPN RCYYKPAEIK LFDGIECEFP IFFLYMMIDG
VFRGNPKQVQ EYQDLLTPVL HHTTEGYPVV PKYYYVPADF VEYEKNNPGS QKRFPSNCGR
DGKLFLWGQA LYIIAKLLTD ELISPKDIDP VQRYVPLKDQ RNVSMRFSNQ GPLENDLVVH
VALIAESQRL QVFLNTYGIQ TQTPQQVEPI QIWPQQELVK AYLQLGINEK LGLSGRPDRP
IGCLGTSKIY RILGKTVVCY PIIFDLSDFY MSQDVFLLID DIKNALQFIK QYWKMHGRPL
FLVLIREDNI RGSRFNPILD MLAALKKGII GGVKVHVDRL QTLISGAVVE QLDFLRISDT
EELPEFKSFE ELEPPKHSKV KRQSSTPSAP ELGQQPDVNI SEWKDKPTHE ILQKLNDCSC
LASQAILLGI LLKREGPNFI TKEGTVSDHI ERVYRRAGSQ KLWSVVRRAA SLLSKVVDSL
APSITNVLVQ GKQVTLGAFG HEEEVISNPL SPRVIQNIIY YKCNTHDERE AVIQQELVIH
IGWIISNNPE LFSGMLKIRI GWIIHAMEYE LQIRGGDQPA LDLYQLSPSE VKQLLLDILQ
PQQNGRCWLN RRQIDGSLNR TPTGFYDRVW QILERTPNGI IVAGKHLPQQ PTLSDMTMYE
MNFSLLVEDT LGNIDQPQYR QIVVELLMVV SIVLERNPEL EFQDKVDLDR LVKEAFNEFQ
KDQSRLKEIE KQDDMTSFYN TPPLGKRGTC SYLTKAVMNL LLEGEVKPNN DDPCLIS
//
