ID G3SDN4_GORGO Unreviewed; 99 AA.
AC G3SDN4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=High mobility group nucleosome-binding domain-containing protein 3 {ECO:0000256|ARBA:ARBA00022145};
GN Name=HMGN3 {ECO:0000313|Ensembl:ENSGGOP00000026214.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000026214.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000026214.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000026214.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000026214.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to nucleosomes, regulating chromatin structure and
CC consequently, chromatin-dependent processes such as transcription, DNA
CC replication and DNA repair. Affects both insulin and glucagon levels
CC and modulates the expression of pancreatic genes involved in insulin
CC secretion. Regulates the expression of the glucose transporter SLC2A2
CC by binding specifically to its promoter region and recruiting PDX1 and
CC additional transcription factors. Regulates the expression of SLC6A9, a
CC glycine transporter which regulates the glycine concentration in
CC synaptic junctions in the central nervous system, by binding to its
CC transcription start site. May play a role in ocular development and
CC astrocyte function. {ECO:0000256|ARBA:ARBA00025168}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HMGN family.
CC {ECO:0000256|ARBA:ARBA00007696}.
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DR EMBL; CABD030046206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030046207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018885403.1; XM_019029858.1.
DR AlphaFoldDB; G3SDN4; -.
DR Ensembl; ENSGGOT00000026029.2; ENSGGOP00000026214.1; ENSGGOG00000006910.3.
DR GeneID; 101125698; -.
DR CTD; 9324; -.
DR eggNOG; ENOG502S1R1; Eukaryota.
DR GeneTree; ENSGT00950000182802; -.
DR HOGENOM; CLU_141985_2_2_1; -.
DR OrthoDB; 4616133at2759; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000006910; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR InterPro; IPR000079; HMGN_fam.
DR PANTHER; PTHR23087:SF2; HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR23087; NONHISTONE CHROMOSOMAL PROTEIN HMG; 1.
DR Pfam; PF01101; HMG14_17; 1.
DR PRINTS; PR00925; NONHISHMG17.
DR SMART; SM00527; HMG17; 1.
DR PROSITE; PS00355; HMG14_17; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 99 AA; 10666 MW; ACC44835523B9C21 CRC64;
MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK EPGAKISRGA
KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNEGE
//
