ID G3SHF4_GORGO Unreviewed; 876 AA.
AC G3SHF4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSGGOP00000027542.2};
GN Name=ANKLE2 {ECO:0000313|Ensembl:ENSGGOP00000027542.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027542.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027542.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027542.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000027542.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ANKLE2 family.
CC {ECO:0000256|ARBA:ARBA00007597}.
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DR EMBL; CABD030087765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030087766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030087767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018893853.1; XM_019038308.1.
DR RefSeq; XP_018893854.1; XM_019038309.1.
DR AlphaFoldDB; G3SHF4; -.
DR Ensembl; ENSGGOT00000027836.2; ENSGGOP00000027542.2; ENSGGOG00000010050.3.
DR eggNOG; ENOG502QQ4Z; Eukaryota.
DR GeneTree; ENSGT00390000016767; -.
DR TreeFam; TF317729; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000010050; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd12944; LEM_ANKL2; 1.
DR Gene3D; 1.10.720.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR InterPro; IPR035006; LEM_ANKL2.
DR InterPro; IPR003887; LEM_dom.
DR InterPro; IPR011320; RNase_H1_N.
DR InterPro; IPR037056; RNase_H1_N_sf.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01693; Cauli_VI; 1.
DR Pfam; PF03020; LEM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF63451; LEM domain; 1.
DR PROSITE; PS50954; LEM; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 7..51
FT /note="LEM"
FT /evidence="ECO:0000259|PROSITE:PS50954"
FT REGION 547..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 97521 MW; 17DCAD534B09E72C CRC64;
MTMDALLARL KLLNPDDLRE EIVKAGLKCG PITSTTRFIF EKKLAQALLE QGGSLSSFYH
HEAGVTTLSQ DPQRILKPAE GNPTDQAGFS EDRDFGYSVG LNPPEEEAVT SKTCSVPPSA
TDTYRAGATA SKEPPLYYGV CQVYEDVPAR NERIYVYENK KEALQAVKMI KGSRFKAFST
REDAEKFARG ICDYFPSPSK TSLPLSPVKT APPFSNDGLK DGLCLSESET VNKERANSYK
NPRTQDLTAK LRKAVEKGEE DTFSDLIWSN PRYLIGSGDN PTIVQEGCRY NVMHVAAKEN
QASICQLTLD VLENPDFMRL MYPDDDEAML QKRVRYVVDL YLNTPDKMGY DTPLHFACKF
GNADVVNVLS SHHLIVKNSR NKYDKTPEDV ICERSKNKSV ELKERIREYL KGHYYVPLLR
AEDTSSPVIG ELWSPDQTAE ASHISRYGGS PRDPVLTLRA FAGPLSPAKA EDFRKLWKTP
PREKAGFLHH VKKSDPERGF ERVGRELAHE LGYPWVEYWE FLGCFVDLSS QEGLQRLEEY
LTQQEIGKKA QQETGEREAS CRDKATTSGS NSISVRAFLD EDDMSLEEIK NRQNASRNNS
PPTVGAFGHT RCSAFPLEQE ADLIEAAEPG GPHSSRNGLC HPQSHSRTLA GKRPKAPRGE
EVHLPPVSDL TVEFDKLNLQ NVGSSVSKTP DENTKTKDKI LTSRINAVER DLLEPSPADQ
LGNGHRRTES EMSARIAKMS LSPSSPRHED QLEVTREPAR RLFLFGEEPS KLDQDVLAAL
ECADVDPHQF PAVHRWKSAV LCYSPSDRQS WPSPAVKGRF KSQLPDLSGP HSYSPGRNSV
AGSNPAKPGL GSPGRYSPVH GGQFRRMARL AELAAL
//
