ID G3SMA0_LOXAF Unreviewed; 1704 AA.
AC G3SMA0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=ATP binding cassette subfamily A member 3 {ECO:0000313|Ensembl:ENSLAFP00000000618.4};
GN Name=ABCA3 {ECO:0000313|Ensembl:ENSLAFP00000000618.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000618.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000000618.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000618.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000000618.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000618.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSLAFT00000000733.4; ENSLAFP00000000618.4; ENSLAFG00000000732.4.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155289; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; G3SMA0; -.
DR OMA; VCPQDDA; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0097233; C:alveolar lamellar body membrane; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0140345; F:phosphatidylcholine flippase activity; IEA:Ensembl.
DR GO; GO:0120019; F:phosphatidylcholine transfer activity; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0070925; P:organelle assembly; IEA:Ensembl.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:Ensembl.
DR GO; GO:0046471; P:phosphatidylglycerol metabolic process; IEA:Ensembl.
DR GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
DR GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
DR GO; GO:1902995; P:positive regulation of phospholipid efflux; IEA:Ensembl.
DR GO; GO:0032464; P:positive regulation of protein homooligomerization; IEA:Ensembl.
DR GO; GO:0046890; P:regulation of lipid biosynthetic process; IEA:Ensembl.
DR GO; GO:0150172; P:regulation of phosphatidylcholine metabolic process; IEA:Ensembl.
DR GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
DR GO; GO:0046618; P:xenobiotic export from cell; IEA:Ensembl.
DR GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF98; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA3; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1183..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1214..1234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 529..762
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1381..1614
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1704 AA; 191783 MW; BD7F0101125550B5 CRC64;
MAVLQQLALL LWKNYTLQKR KVVVTVLEIF LPLLFSGILI WLRLKIQSEN VSNASMFPFN
IKKHCPFFPF YFASTSHWRL VQFSKHFDEV PQSLAVRSQS NLEVHIRGFP SEEDFEYYIK
YNNCSSNVLA AVVFEHTFNH SRDPLPLAVK YHLRFSYTRR NYMWTKTGSF FLKDTEGWHT
TSLFPLFPNP GPREPTSPDG GEPGYIREGF LAVQHAVDRA IMQYHANTAT HQLFHTVTVI
AKRFPYPPFI SDPFLVAIQY QFPLLLMLSF TYTSLTIIRA VVQEKEKKLK EYMHMMGLSS
WLHWSAWFLL FFLFLLIAVS FITLLFCIKV KKNMAVLTNS DPSLVLVFLL CFSISSISFS
FMVSTFFSKA NMAAAIGGFL YFFTYIPYFF VAPRYNWMTL SQKLFSCLLS NVAMAMGAQL
IGKFEAKGTG LQWRNLLSPV SVDDNFSFGQ VLGMLLFDAV LYGLVAWYVE AICPGQFGVP
QPWYFFFTPS YWCRSLRTIL VKEDKDDDPE KVLRMEFFEA EPEDLVAGIK IKHLSKVFRV
GNKGKVAVRD LNLNLYEGQI TVLLGHNGAG KTTTLSMLTG LFPPTSGWAY ISGYEISQDM
AQIRKSLGLC PQHDILFDDL TVVEHLYFYA QLKGLSLQKC QEEVRHMLRT LDLEDKQDSL
SKFLSGGMRR KLSIGIALIA GSKVLMLDEP TSGMDAISRR AIWDLLQQQK SDRTILLTTH
FMDEADLLGD RIAIMAKGEL QCCGSSLFLK QKYGAGYHMT LVKEPHCDPE AVSQLVHHHV
PNATLESSAG AELSFILPKE STHRFETLFT KLEKNQKELG IASFGASITT MEEVFLRVGK
LVDTSMDIQA IQLPALQYQH ERRASDWAVD SHLSGMMDPS DGAGALIEED CGAIQLNTGL
ALHCQQFWAM FMKKAVYSWR EWKVVAAQVL VPLTCLTLAL LAINYSSEIL DDPSLELTLG
EYGTTVVPFS APGTSQLDQQ LSEHLRDMLQ AEGQEPREVL GDLEEFLIFR ASVEGGGFNE
RCLVATSFRD VGERTVITAL FNNQAYHSPA TALAVVDNLL FKLLCGPRAS ITVSNYPQPR
STLQAAKDQF NEGRKGFHIA LNLLFAMAFL ASTFSILAVS ERATQAKHVQ FVSGVHVATF
WLSALLWDLI SFLVPSLLLL VVFKAFDVHA FTQDGHEADA LALLLLYGWA IIPLMYLMSF
LFSGAATAYT RLTIFNILSG IATFLVVTIM RIPAVKLEEL SRTLDQVFLV LPNHCLGMAI
SSFYENYETR RYCTSSEVAT HYCQKYHIEY QENFYAWRAP GVGRFVTSMA VSGFIYLTIL
FLLETDLLWR LKNLLCAFRG RRMLMDSYSR APALPEDQDV ADERSRVLAP TLDTPPRDPP
LVIQELSKVY EQRTPLLAVD KLSLAVQKGE CFGLLGFNGA GKTTTFKMLT GEETITSGDA
FVGGHSIRSD LGKVRQRIGY CPQFDALLDH LTAWETLVMY ARLRGIPEHH IGSCVENMLR
GLLLEPHANK LVRTYSGGNK RKLSTGIALI GDPTVIFLDE PSTGMDPVAR RLLWDTVVRA
RESGKAIIFT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH LKSKFGSGYS LRAKVRVDGQ
KAAPEVFKAF VDLTFPGSIL EDEHQGMVHY HLPSHGLSWA KVFGVLEKAK EKYGVDDYSV
SQISLEQVFL SFAHLQPPAQ DEGQ
//
