ID G3SNW3_LOXAF Unreviewed; 1824 AA.
AC G3SNW3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Latent transforming growth factor beta binding protein 2 {ECO:0000313|Ensembl:ENSLAFP00000001345.3};
GN Name=LTBP2 {ECO:0000313|Ensembl:ENSLAFP00000001345.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001345.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001345.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001345.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001345.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001345.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9785.ENSLAFP00000001345; -.
DR Ensembl; ENSLAFT00000001612.3; ENSLAFP00000001345.3; ENSLAFG00000001609.3.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160884; -.
DR HOGENOM; CLU_001884_1_0_1; -.
DR InParanoid; G3SNW3; -.
DR OMA; ADPPHCA; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0097435; P:supramolecular fiber organization; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 19.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF111; FIBRILLIN-3; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 17.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 18.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 12.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1824
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003454042"
FT DOMAIN 187..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 390..422
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 550..593
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 670..722
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 846..888
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 889..925
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 932..971
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1012..1052
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1137..1177
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1178..1219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1220..1255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1305..1346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1413..1465
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1487..1529
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1530..1569
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1586..1638
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1777..1821
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 38..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 191..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 394..404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 412..421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1534..1544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1824 AA; 196974 MW; 71AF02B44452C809 CRC64;
MRPPPAARCP ELLLQNLWKG FLPLLLALFV GMSYAQRDPV GRYQPTGRDA NRLRRPGGSH
PVAASAKVYS LFREQNASVP GLPSEEPPQR GWGSPRNSAE AEARRPSSAQ HPRGVQPPAQ
PRRRSPQGQQ QPTAWSRAAP ALRRLRTSQR PGAAPPTPPR RRLTGRNVCG GQCCPGWTTA
NSTNHCIKPV CQPPCQNRGF CSRPQLCICR SGFRGARCEE VIPEEEFDPQ NSRPAPRRSA
EGSPNLRRSN AAREDTMART RPPAPQPPLP GTLSGLSQTR PSQQQVGLSR TVRRYPAAAA
SGQLTSNALP VGPGPEQRQG AQQAAYLGQV SSAWGLNLTE KIKKIKIVFT PTICKQTCAR
GHCANSCERG NTTTLYSQGG HGHDPKSGFR IYFCQIPCLN GGHCIGRDEC WCPANSTGKF
CHLPIPKPER KPPEGVSHHW ALLESPLKQS TFTLPLSNQV APLPSRHEPL HGKVHIRHPP
EASVQIHQVA RVRGEAEEAR EDNTVETRPL PRLPASPGHS RWDSNSIPTR SGQPVRPPPP
AAHRPWGPLG RCYLSAVNGQ CANPLLELTP QEDCCGSVGA FWGVTSCSPC PPRPAAPVIE
NGQVECPQGY KRLNLTHCQD INECFVLGLC KDSECVNTRG SYICTCRPGL MLDPSRSRCV
SDKAVSMQQG LCYRSLGPHT CTLPLAHRIT KQICCCSRVG KAWGPGCEKC PSPGTEAFRE
ICPAGHGYTY SSSDIRLSMR KAEEEELARP SREQGQKSNR TLPGSAERQP LRAATSTWLE
AGTIPDKGDS QDGQVTTSVT HAPIWVPADA MRRPTPPLPA QEIPETWEEE QVTSRTDVLV
TLGPPGIDKC ATGATNICGP GTCVNLPDGY RCVCSPGYRL HPSQAYCTDD NECLREPCAG
KGRCVNSVGS YSCICYPGYM LATSGATQDC QDIDECEQPG VCTRGRCTNT EGSYHCECDQ
GYIMVRKGHC QDINECSQPG TCPDGRCVNS PGSYTCLACE EGYRGQSGSC VDVNECLTPG
VCAHGRCINL DGSFKCSCEQ GYEVTSDEKS CQDVNECTSR AACPTGLCLN TEGSFSCSAC
ESGYWVNEDG TACEDLDECA FPGVCPTGVC TNTVGSFSCK DCDRGYRPSP LGHTCEDVDE
CEDPQSSCLG GKCKNVAGSY QCLCPPGFQL ANGTVCEDVD ECVGEEYCAP HGECLNSHGS
FFCLCAPGFA STAGGTSCQD VDECAATDRC LGGQCVNTEG SFNCLCETGF QPSPESGECV
DIDECEDYSD SVCGAWKCEN SPGSFHCVLG CQLGFHMTPT GDCIDIDECA NDTVCGSHGF
CDNSDGSFRC LCDQGFETSP SGWDCVDVNE CELMLAVCGA AFCENVEGSF LCLCPSDLEE
YDAQEGRCHP RAAGGQSIPE APTVDHPTGP IRMECYSGQK GQPPCTSILG RNTTQAECCC
TQGASWGDTC ELCPSEDSVE FSEICPSGKG YIPVEGAWMF GQTTYTDADE CVMFGPDLCQ
NGRCLNTVPG YTCLCDPGYS YDASRKKCED HDECQAMACE NGECVNTEGS FHCFCSPPLI
LDPSRQRCVN GTSSMDDLPD HDIHLDICWK TVTNYVCSQP LRGRRTTYTE CCCQDGEAWS
QQCALCPPRS SEVYAQLCNV ARIEAEREAG VHFRPGYEYG PGPDDLQYSL YGPDGAPFYN
YLGPEDNIPE PPFPNTASHP GDHTPVLESP LQPPEAQPHY VASHPAEHQA GFEGLQAEEC
GILNGCENGR CVRVREGYTC DCFEGFQLDA AHMACVDVNE CEDLNGPAAL CAHGHCENME
GSYRCHCTPG YVAKADPPHC AAKE
//
