ID G3SRG1_LOXAF Unreviewed; 410 AA.
AC G3SRG1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=NFKB activating protein {ECO:0000313|Ensembl:ENSLAFP00000002468.2};
GN Name=NKAP {ECO:0000313|Ensembl:ENSLAFP00000002468.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002468.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000002468.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002468.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000002468.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002468.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NKAP family.
CC {ECO:0000256|ARBA:ARBA00009313}.
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DR RefSeq; XP_003414822.1; XM_003414774.2.
DR AlphaFoldDB; G3SRG1; -.
DR STRING; 9785.ENSLAFP00000002468; -.
DR Ensembl; ENSLAFT00000002961.2; ENSLAFP00000002468.2; ENSLAFG00000002962.2.
DR GeneID; 100662015; -.
DR KEGG; lav:100662015; -.
DR CTD; 79576; -.
DR eggNOG; KOG2812; Eukaryota.
DR GeneTree; ENSGT00940000160787; -.
DR HOGENOM; CLU_032439_1_0_1; -.
DR InParanoid; G3SRG1; -.
DR OMA; VERWPND; -.
DR OrthoDB; 2883730at2759; -.
DR TreeFam; TF315333; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
DR InterPro; IPR040466; NKAP.
DR InterPro; IPR009269; NKAP_C.
DR PANTHER; PTHR13087; NF-KAPPA B ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR13087:SF2; NF-KAPPA-B-ACTIVATING PROTEIN; 1.
DR Pfam; PF15692; NKAP; 1.
DR Pfam; PF06047; Nkap_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 303..400
FT /note="NF-kappa-B-activating protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06047"
FT REGION 1..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..44
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..201
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..252
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46651 MW; 32A04BAFB14C090B CRC64;
MAPVSGSRTP EREASGSGGK RRSLSRSPKP TRAARSPRSH HSRSHSSSRS GDRNGLSQSS
RNQPYRSRSR SRSRERPSGP RGTPFASATS SGYYGGYSRP YGSDKPWPSL LDKEREESLR
QKRLSERERI GELGAPEVWG LSPKNPEPDS DEHTPVEDDE PKKSTSSAST SEEEKKKKKK
SGRSKERLKK RRKKKSSKRK HKKYSDDSDS DSDSETDSSD EDTKRRAKKN KKKEKKKKHR
SKKYKKKKSK KNRKESSDSS SKDSQEEFLE NPWKDRSKPE EPSDLIGPEA PKTLASQDDK
PLNYGHALLP GEGAAMAEYV KAGKRIPRRG EIGLTSEEIA SFECSGYVMS GSRHRRMEAV
RLRKENQIYS ADEKRALASF NQEERRKREN KILASFREMV YRKTKGKDDK
//
