ID G3STD6_LOXAF Unreviewed; 628 AA.
AC G3STD6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Rap1 GTPase-GDP dissociation stimulator 1 {ECO:0000313|Ensembl:ENSLAFP00000003309.3};
GN Name=RAP1GDS1 {ECO:0000313|Ensembl:ENSLAFP00000003309.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003309.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000003309.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003309.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000003309.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003309.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
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DR AlphaFoldDB; G3STD6; -.
DR STRING; 9785.ENSLAFP00000003309; -.
DR Ensembl; ENSLAFT00000003962.3; ENSLAFP00000003309.3; ENSLAFG00000003961.3.
DR eggNOG; KOG4500; Eukaryota.
DR GeneTree; ENSGT00390000014293; -.
DR HOGENOM; CLU_021124_1_0_1; -.
DR InParanoid; G3STD6; -.
DR OMA; IAWLINN; -.
DR TreeFam; TF323666; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0086098; P:angiotensin-activated signaling pathway involved in heart process; IEA:Ensembl.
DR GO; GO:0080120; P:CAAX-box protein maturation; IEA:Ensembl.
DR GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
DR GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0070376; P:regulation of ERK5 cascade; IEA:Ensembl.
DR GO; GO:1904464; P:regulation of matrix metallopeptidase secretion; IEA:Ensembl.
DR GO; GO:0010821; P:regulation of mitochondrion organization; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040144; RAP1GDS1.
DR PANTHER; PTHR10957; RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1; 1.
DR PANTHER; PTHR10957:SF2; RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50176; ARM_REPEAT; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 110..152
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 378..410
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 628 AA; 68329 MW; CAA13BB461D52A04 CRC64;
TAPPAPETFA APYRSSLSGR NMDNLSDTLK KLKITAVDRT EDSLEGCLDC LLQALAQNNT
GTSEKIQGSG ILQLFADLLT PQSSCTAKVA NIIAEVAKNE FMRIPCVEAG LISPLVQLLN
SKDQEVLLQT GRALGNICYD SHEGRSAVDQ AGGAQIVIDH LRSLCGITDP ANEKLLTVFC
GMLMNYSNEN DSLQAQLINM GVIPTLVKLL GIHCQNAALT EMCLVAFGNL AELESSKEQF
ASTNIAEELV KLFKKQIEHD KREMIFEVLA PLAENDAIKL QLVESGLVEC LLEIVQQKVD
SDKEDDIAEL KTASDLMVLL LLGDESMQKL FEGGKGNVFQ KVLSWIPSSN HQLQLAGALA
IANFARNDGN CIHMVDNGIV ENLMDLLNRH VEDGNVTVQH AALSALRNLA IPVVNKGKML
SAGVTEAVLK FLKSEMPPVQ FKLLGTLRML IDAQAEAAEQ LGKNVKLVER LVEWCEAKDH
AGVMGESNRL LSALIRHSKS KDVIKTIVQS GGIKHLVTMA TSEHVIMQNE ALVALALIAA
LELGTAEKDL ESAKLVRILH RLLADERSAP EIKYNSMVLI CAVMGSESLH KEVQDLAFLD
VVSKLRSHEN KSVAQQASLT EQRLTVES
//
