ID G3T2I1_LOXAF Unreviewed; 430 AA.
AC G3T2I1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Small ArfGAP2 {ECO:0000313|Ensembl:ENSLAFP00000007378.2};
GN Name=SMAP2 {ECO:0000313|Ensembl:ENSLAFP00000007378.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007378.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007378.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007378.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007378.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007378.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003415575.1; XM_003415527.2.
DR AlphaFoldDB; G3T2I1; -.
DR STRING; 9785.ENSLAFP00000007378; -.
DR Ensembl; ENSLAFT00000008783.2; ENSLAFP00000007378.2; ENSLAFG00000008783.2.
DR GeneID; 100661842; -.
DR KEGG; lav:100661842; -.
DR CTD; 64744; -.
DR eggNOG; KOG0703; Eukaryota.
DR GeneTree; ENSGT00940000158387; -.
DR HOGENOM; CLU_023062_5_0_1; -.
DR InParanoid; G3T2I1; -.
DR OMA; MMGYGQS; -.
DR OrthoDB; 1022106at2759; -.
DR TreeFam; TF313876; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd08859; ArfGap_SMAP2; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR45705; FI20236P1; 1.
DR PANTHER; PTHR45705:SF4; STROMAL MEMBRANE-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 13..137
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 137..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 46948 MW; 799A474499C17DAD CRC64;
MTGKSVKDVD RYQAVLANLL LEEDNKFCAD CQSKGPRWAS WNIGVFICIR CAGIHRNLGV
HISRVKSVNL DQWTQEQIQC MQEMGNGKAN RLYEAYLPET FRRPQIDLAV EGFIRDKYEK
KKYMDRSLDI NAFRKEKDDK WKRGSEPAPE KKMEPVVFEK VKMPQKKEDP QLPRKSSPKS
TAPVMDLLGL DAPVACSIAN SKTSNTLEKD LDLLASVPSP SSSVSRKVVG SMPTAGSAGS
VPENLNLFPE PGSKSEETGK KQLSKDSILS LYGSQTPQMP AQAMFMAPAQ MAYPTAYPTF
PGVTPPNSIM GSMMPPPVGM VTQPGASGMV AAPMAMPAGY MGGMQASMMG VPNGMMTTQQ
AGYMAGLAAM PQTMYGVQPA QQLQWNLTQM TQQMAGMNFY GANGMMNYGQ SMNGGNGQAA
NQTLSPQMWK
//
