ID G3T3K5_LOXAF Unreviewed; 1151 AA.
AC G3T3K5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Tight junction protein 2 {ECO:0008006|Google:ProtNLM};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007842.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007842.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007842.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007842.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007842.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_010585839.1; XM_010587537.1.
DR AlphaFoldDB; G3T3K5; -.
DR STRING; 9785.ENSLAFP00000007842; -.
DR Ensembl; ENSLAFT00000009359.3; ENSLAFP00000007842.3; ENSLAFG00000009356.3.
DR GeneID; 100665016; -.
DR CTD; 9414; -.
DR eggNOG; KOG3580; Eukaryota.
DR GeneTree; ENSGT00940000155164; -.
DR HOGENOM; CLU_006234_1_0_1; -.
DR InParanoid; G3T3K5; -.
DR OMA; RQRHSKI; -.
DR OrthoDB; 2904077at2759; -.
DR TreeFam; TF315957; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12027; SH3_ZO-2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR InterPro; IPR035598; ZO-2_SH3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 10..97
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 269..347
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 470..551
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 565..630
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 735..837
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 128..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..902
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 129523 MW; AE4F0D00B6E38A2D CRC64;
MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG PADGLLQEND
RVVMVNGTPM EDVLHSFAVQ QLRKSGKIAV IVVKRPRKVQ LAPLQNSPPV DHDDRAFEVM
DEFDGRSARS GYSERSWHSS HGARSRSWDE SPDRGHPHDR ARSRERLPSQ DRSRGQSLER
GLDHDYRGAR DSSRGRSIDR EGSYERTYNQ AYDRPYSPSV EYSRRAQVDA RYEMSRSHSR
EHLYSRSPSP ELRGRPAHTG QQDSDRPIGV LLTKSKANEE YGLRLGSQIF IKEMTQTGLA
FKDGNLHEGD IILKINGTVS ENMSLTDARK LIEKSRGKLQ LVVWRDSKQT LVNIPSLNDS
DSEMEDISEI ESNRSFSPDE RRQQYSDYDY HSSNEKLKER PSSREDTSGR LSRMGATPTP
FKSTGDIAAA VIETSKEPRH QEEPPAPQPK PAPRIFNRPS PEDEAIYGPN TKMVRFKKGD
SVGLRLAGGN DVGIFVAGIQ EGTSAEQEGL EEGDQILKVN TQDFRGLVRE DAVLYLLEIP
KGEVVTLLAQ SRADVYRDIL ACGRGDSFFI RSHFECEKET PQSLAFTRGE VFRVVDTLYD
GKLGHWLAVR IGNELEKGLI PNKSRAEQMA SVQNAQRDNA GDRADFWRMR GQRSGVKKNL
RKSREDLTAA VSVSTKFPAY ERVLLREAGF KRPVVFFGPI ADIAMEKLAN ELPDLFQTAK
TEPKDAGSEK SSGVVRLNTV RQIIEQDKHA LLDVTPKAVD LLNYTQWFPI VIFFNPDSRQ
GVKTMRQRLN PSSNKSSRKL YDQANKLKKT CAHLFTATIN LNSANDSWFG SLKDTIQHQQ
GEAVWVSEGK MEGMDDDPED RMSYLTAMGA DYLSCDSRLI SDFEDTDGEG GAYTDNELDE
PAEEPLGSSI SRSSEPVQHE ESIRKPSPEP RAQMRRAASR DQLRDNSPPP TFKPEPPKAR
TQNREEFHDF SKSYEYKPNP STVATNEIPV ASTRGYPPPV AVKPAFGRPI LKPSTPSPAL
ESEETGEGSE EQETTPRSVL GKVKIFEKMD HKAKLQRMQE LQEAQNARIE IAQKHPDIYA
VPIKTQKPDP GLPQHTSSRP PEPQKGPSRL YQDTRGSYSS DAEEEEYRQQ LSEHSKRGYY
GQAAQYRDTE L
//
