ID G3T5T7_LOXAF Unreviewed; 1355 AA.
AC G3T5T7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Calcium dependent secretion activator {ECO:0000313|Ensembl:ENSLAFP00000008824.4};
GN Name=CADPS {ECO:0000313|Ensembl:ENSLAFP00000008824.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008824.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000008824.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008824.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000008824.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008824.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000008824; -.
DR Ensembl; ENSLAFT00000010541.4; ENSLAFP00000008824.4; ENSLAFG00000010539.4.
DR eggNOG; KOG3543; Eukaryota.
DR GeneTree; ENSGT00950000183306; -.
DR InParanoid; G3T5T7; -.
DR OMA; LYQCTCL; -.
DR TreeFam; TF312963; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:1990504; P:dense core granule exocytosis; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:InterPro.
DR CDD; cd01234; PH_CADPS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR033227; CAPS.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12166; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR PANTHER; PTHR12166:SF6; CALCIUM-DEPENDENT SECRETION ACTIVATOR 1; 1.
DR Pfam; PF06292; MUN; 2.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01145; DUF1041; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 373..488
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 514..617
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 934..1113
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1355 AA; 153279 MW; D8B6BC9479BF600A CRC64;
MLDPSSSEEE SDEIVEEESG KEVLGSAASG ARLSPSRTSE GSAGGAGLGG SGAGVGAGGG
GGSGPGSGGA GGLQPSSRAG GGRPSSPSPS VVSEKEKEEL ERLQKEEEER KKRLQLYVFV
RCIAYPFNKQ PTDMARRQQX ISKQQLQTVK DRFQAFLNGE TQIVADEAFM NAVQSYYEVF
LKSDRVARMV QSGGCSANDS REVFKKHIEK RVRSLPEIDG LSKETVLSSW MAKFDAIYRG
EEDPRKQQAR MTASAASELI LSKEQLYEMF QNILGIKKFE HQLLYNACQL DNPDEQAAQI
RRELDGRLQM ADQIARERKF PKFVSKEMEN MYIEELKSSV NLLMANLESM PVSKGGEFKL
QKLKRSHNTS IIDLGEESEN QLSKSDVVLS FSLEVVIMEV QGLKSLAPNR IVYCTMEVEG
GEKLQTDQAE ASKPTWGTQG DFSTTHALPA VKVKLFTEST GVLALEDKEL GRVILHPTPN
SPKQSEWHKM TVSKNCPDQD LKIKLAVRMD KPQNMKHSGY LWAIGKNVWK RWKKRFFVLV
QVSQYTFAMC SYREKKAEPQ ELLQLDGYTV DYTDPQPGLE GGRAFFNAVK EGDTVIFASD
DEQDRILWVQ AMYRATGQSH KPVPPTQVQK LNAKGGNVPQ LDAPISQFYA DRAQKHGMDE
FISSNPCNFD HAALFETVQR LTLDHRLNDS YSCLGWFSPG QVFVLDEYCA RNGVRGCHRH
LCYLRDLLER AENGAMIDPT LLHYSFAFCA SHVHGNRPDG IGTVTVEEKE RFEEIKERLR
VLLENQITHF RYCFPFGRPE GALKATLSLL ERVLMKDIVT PVPQEEVKTV IRKCLEQAAL
VNYSRLSEYA KIEGKKREMY EHPVFCLASQ VMDLTIQNVG RLITPAKKLE DTIRLAELVI
EVLQQNEEHH AEAFAWWSDL MVEHAETFLS LFAVDMDAAL EVQPPDSWDS FPLFQLLNDS
LRTDHNLCNG KFHKHLQDLF APLVVRYVDL MESSIAQSIH RGFERESWEP VNFFHRSLTS
NLPSVNLPKV PNLPVNIPLG IPQMPTFSAP SWMAAIYDAD NGSGTSEDLF WKLDALQTFI
RDLHWPEEEF GKHLEQRLKL MASDMIESCV KRTRIAFEVK LQKTSRSTDF RVPQAICTMF
NVMVDAKAQS TKLCSMEMGQ EHQYHSKIDE LIEETVKEMI TLLVAKFVTI LEGVLAKLSR
YDEGTLFSSF LSFTVKAASK YVDVPKPGMD VADAYVTFVR HSQDVLRDKV NEEMYIERLF
DQWYNSSMNV ICTWLTDRMD LQLHIYQLKT LIRMVKKTYR DFRLQGVLDS TLNSKTYETI
RNRLTVEEAT ASVSEGGGLQ GISMKDSDEE DEEDD
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