ID G3TEE3_LOXAF Unreviewed; 823 AA.
AC G3TEE3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Leucine rich repeat containing G protein-coupled receptor 6 {ECO:0000313|Ensembl:ENSLAFP00000012609.3};
GN Name=LGR6 {ECO:0000313|Ensembl:ENSLAFP00000012609.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012609.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012609.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012609.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012609.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012609.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G3TEE3; -.
DR Ensembl; ENSLAFT00000015059.3; ENSLAFP00000012609.3; ENSLAFG00000015055.3.
DR GeneTree; ENSGT00940000159939; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR CDD; cd15362; 7tmA_LGR6; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF73; LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6-RELATED; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00373; GLYCHORMONER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 10.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 823 AA; 89288 MW; 340721C92693DC3C CRC64;
RLDANLISLV PERSFEGLSS LRHLWLDDNA LTEIPVRALN NLPALQAMTL ALNRISHIPD
FAFQNLTSLV VLHLHNNHIQ HLGTHSFEGL HNLETLDLNY NKLQEFPVAI RTLGRLQELG
FHNNNIKAIP EKAFMGNPLL QTIHFYDNPI QFVGRSAFQY LPKLHTLSLN GATDIQEFPD
LKGTTSLEIL TLTSAGIRLL PPGMCQQLPR LRVLELSHNQ IEELPSLHWC QKLEEIGLQH
NRIWEIGADT FSQLSSLRTL DLSWNAIRSI HPEAFTTLRS LVKLDLTDNQ LTTLPLAGLG
GLMHLKLKGN LALSQAFSKD SFPKLRVLEV PYAYQCCAYG VCASFFKASG QWEAEDFHLD
EEETPKRSLG LLAGQAENHL EDDLEELQLE MEDSKPHPSV QCSPVPGPFK PCEHLFESWG
IRLAVWAIVL LSIVCNGLVL LTVFAGGPVP LPPVKFVVGA IAGANTLTGI SCGLLASVDA
LTFGQFAEYG ARWEMGLGCR ATGFLAVLGS EASVLLLTLA TVQCSVSISC VRAYGKAPSL
GSVRAGALGC LMLAGLAAAL PLTSVGEYGA SPLCLPYAPP EGPPEALGFA VALVMMNSCF
LVVAGAYIKL YCDLPRGDFE AVWDCAMVRH VAWLIFADGL LYCPVAFLSF ASMLGLFPVT
PEAVKSVLLV VLPLPACLNP LLYLLFNPHF RDDLRRLRPR TGTPGPLACA AASELEKSSC
DSTQALVAFS DVDLILEASE AGRPPGLETY GFPSVTLISC QQPRGPRLEG SHFVEPEGTY
FGNPQPSMDG ELLLRAEGVT SVGKVLSVGG GFRPSGSSFA SHL
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