ID   G3TG26_LOXAF            Unreviewed;       839 AA.
AC   G3TG26;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000013394.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000013394.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013394.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000013394.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013394.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC       at the centrosome. {ECO:0000256|RuleBase:RU363050}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC   -!- SIMILARITY: Belongs to the TUBGCP family.
CC       {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3TG26; -.
DR   STRING; 9785.ENSLAFP00000013394; -.
DR   Ensembl; ENSLAFT00000015967.3; ENSLAFP00000013394.3; ENSLAFG00000015963.3.
DR   eggNOG; KOG2000; Eukaryota.
DR   GeneTree; ENSGT00940000157810; -.
DR   HOGENOM; CLU_351134_0_0_1; -.
DR   InParanoid; G3TG26; -.
DR   OMA; WSTHGHV; -.
DR   TreeFam; TF106321; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR   Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR   InterPro; IPR007259; GCP.
DR   InterPro; IPR040457; GCP_C.
DR   InterPro; IPR042241; GCP_C_sf.
DR   PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR   PANTHER; PTHR19302:SF70; GAMMA-TUBULIN COMPLEX COMPONENT 6; 1.
DR   Pfam; PF04130; GCP_C_terminal; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU363050};
KW   Microtubule {ECO:0000256|RuleBase:RU363050};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          533..836
FT                   /note="Gamma tubulin complex component C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04130"
FT   REGION          70..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   839 AA;  91713 MW;  82D3985E813C9C5B CRC64;
     LTPGEVPTLA GTQPSQVQEY DFSTILRPAV AALVSPGSLQ ALEGDSGSKG PQLRWDTDTK
     LDARVPEVLA GQPHLPLPRP AEEENSGPQD QPLRHVSEGR VSSVGHASQT APSRPRWSVH
     GHVSDANIKI GENVSDMAPL QPRWNIHGHT SDANVRVGEN VSDVAPSRPQ WSVHGHVSDA
     NIRVGENVSD VAPSRPRWSV HGHVSDANIR VGENVSDVAP SRPRWSIHGH VSDANIRVGE
     NISDVAPSRP RWSVHGHVSD ANIRVGENVS DVVPSRPRWS VHGHVSDSNI RVGENVSDVA
     PSQPRWSVHG HMLLEEAEPE KSGPHLSPSG HVVQSDQGAQ STSLEHPPAE TTPGPLGLSL
     AQVATFGSAE EGGFQAELCT VARPGAPEEH GSEGEPADAP SLPHCARSGS RSSGNSSTAS
     PGQPSSPQAG EAREEWAYLE GLAAQYHLEQ YPDSYEAMSE PPAAHLLPHV LPRSFSFPAD
     PQAQPGTDET AVQLSELLTL PVLLKHSISA PLTAHVSLVN KAAVDYFFVE LHLETHLEAL
     RHFVLMEDGE FAQSLSDLLF EKLGSGQMPG ELLSPLALGS VLSKALQYSL HGDSPLAANL
     SFALKFLPEV FSPNAPDVLS CLELRYKVDW PLNIVITESC LSKYGRIFSF LLQLKLMMWT
     LKDICGHLKR SALVSRVAGS VQFRQLQLFK HEMQHFVKVT QGYIASQILH VTWCEFRNKL
     ATVSTLEEVQ RAHAEYLNKA VFRGLLTEKA APVMNVIHSI FSLVLKFRSQ LISQAWGPTA
     HPRGAEHPNF ALMQQSYNTF KYYSHFLFKV VTKLVNRGYQ PHLEDFLLRI NFNNYYQDA
//