ID G3TMG8_LOXAF Unreviewed; 693 AA.
AC G3TMG8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Neuronal guanine nucleotide exchange factor {ECO:0000313|Ensembl:ENSLAFP00000016307.2};
GN Name=NGEF {ECO:0000313|Ensembl:ENSLAFP00000016307.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016307.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016307.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016307.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016307.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016307.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TMG8; -.
DR STRING; 9785.ENSLAFP00000016307; -.
DR Ensembl; ENSLAFT00000022014.2; ENSLAFP00000016307.2; ENSLAFG00000023223.2.
DR eggNOG; KOG3523; Eukaryota.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_012820_5_1_1; -.
DR InParanoid; G3TMG8; -.
DR OMA; SQTICHS; -.
DR TreeFam; TF316357; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11939; SH3_ephexin1; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035635; Ephexin-1_SH3.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF8; EPHEXIN-1; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 256..440
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 472..584
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 595..656
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 80362 MW; 4ABB70318D80F06F CRC64;
METKASEDPE KPWKKSVRHS WENDEPVKER PELPWKEETH HADQETPEPH RQIPIQRNSI
FNRAIRHRSK TKTRDNSEKN TGHHQAGSLE NGKSANEPLA LKVPQSRTPP WRIPTQTDPA
AQKTSESSST PGNGTTPEEC PALADSPTTL TEALQRIHPI PADSWRNLIE QIGLLYQEYR
DKSTLQEIET RRQQDAEIHD RSPASVEAPP ASPPERKALP QICLLSNPHS RFNLWQDLPE
IRSSGVLEIL QPEEVKLQEA MFELVTSEAS YYKSLNLLVS HFVENERLKK VLHPAEAHLL
FSNVLDVTAV SERFLLELEH RMEENIVISD VCDIVYRYAA NHFSVYITYV SNQTYQERTY
KQLLQEKAAF RELIAQLELD PKCKGLPFSS FLILPFQRIT RLKLLVQNIL KRVEEGSERE
CTAQDAHKEL EMVVKACNEG VRKMSRTEQM VSIQRKMEFK IKSVPIISHS RWLLKQGELQ
QMSGPKTSRT LRTKKLFREI YLFLFNDLLV ICRQIPGDKY QVFDSASRGL LRVEELEDQG
QTLANVFILR LLENADDREA TYMLKASSQS EMKRWMTSLA PNRRTKFVSF TSRLLDCPQV
QCVHPYVAQQ PDELTLELAD ILNILDKTED GWIFGERLHD QERGWFPSSM TEEILNPKIR
SQNLKECFRV HKMEDPQRSQ NKDRRKLGSR NRQ
//
