ID G3TT92_LOXAF Unreviewed; 472 AA.
AC G3TT92;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 6 {ECO:0000256|ARBA:ARBA00016259};
GN Name=CPSF6 {ECO:0000313|Ensembl:ENSLAFP00000018800.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018800.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018800.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018800.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018800.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018800.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the RRM CPSF6/7 family.
CC {ECO:0000256|ARBA:ARBA00006265}.
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DR AlphaFoldDB; G3TT92; -.
DR Ensembl; ENSLAFT00000025612.1; ENSLAFP00000018800.1; ENSLAFG00000030413.1.
DR GeneTree; ENSGT00730000110905; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12643; RRM_CFIm68; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034772; CPSF6/7.
DR InterPro; IPR034769; CPSF6_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23204; CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR; 1.
DR PANTHER; PTHR23204:SF3; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 396..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..161
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 173..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..300
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 51484 MW; 9737AE3148C239D4 CRC64;
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKNLRPKAP
ATTQSGQMSG EGAVPGGDRF PGPAGPGGPP PPFPGQPFGQ PPLGPLPPGP PPPVPGYGPP
PGPPPPQQGP PPPPGPFPPR PPGPLGPPLT LAPPPHLPGP PPGAPPPAPH VNPAFFPPPT
NSGMPTSDSR GPPPTDPYGR PPPYDSYREM DTARTPLSEA EFEEIMNRNR AISSSAISRA
VSDASAGDYG SAIETLVTAI SLIKQSKVSA DDRCKVLFFL LAEVLMCLIF KSYCSSVISF
RRRERSRERD HSRSREKSRR HKSRSRDRHD DYYRERSRER ERHRDRDRDR DR
//
