ID G3TWK4_LOXAF Unreviewed; 1729 AA.
AC G3TWK4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Meiosis regulator and mRNA stability factor 1 {ECO:0000256|ARBA:ARBA00022152};
DE AltName: Full=Limkain-b1 {ECO:0000256|ARBA:ARBA00030116};
GN Name=MARF1 {ECO:0000313|Ensembl:ENSLAFP00000019962.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019962.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000019962.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019962.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000019962.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019962.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR Ensembl; ENSLAFT00000026430.1; ENSLAFP00000019962.1; ENSLAFG00000017524.4.
DR GeneTree; ENSGT00390000002393; -.
DR HOGENOM; CLU_002701_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR CDD; cd09977; LOTUS_1_Limkain_b1; 1.
DR CDD; cd09978; LOTUS_2_Limkain_b1; 1.
DR CDD; cd09979; LOTUS_3_Limkain_b1; 1.
DR CDD; cd09980; LOTUS_4_Limkain_b1; 1.
DR CDD; cd09981; LOTUS_5_Limkain_b1; 1.
DR CDD; cd09982; LOTUS_6_Limkain_b1; 1.
DR CDD; cd09983; LOTUS_7_Limkain_b1; 1.
DR CDD; cd09984; LOTUS_8_Limkain_b1; 1.
DR CDD; cd10910; PIN_limkain_b1_N_like; 1.
DR CDD; cd12255; RRM1_LKAP; 1.
DR CDD; cd12256; RRM2_LKAP; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 6.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR024768; Marf1.
DR InterPro; IPR045602; MARF1_LOTUS.
DR InterPro; IPR034189; MARF1_RRM1.
DR InterPro; IPR034191; MARF1_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021139; NYN.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR14379; LIMKAIN B LKAP; 1.
DR PANTHER; PTHR14379:SF82; MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1; 1.
DR Pfam; PF19687; MARF1_LOTUS; 1.
DR Pfam; PF11608; MARF1_RRM1; 1.
DR Pfam; PF01936; NYN; 1.
DR Pfam; PF12872; OST-HTH; 5.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS51644; HTH_OST; 7.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Oogenesis {ECO:0000256|ARBA:ARBA00022943};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 781..860
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 993..1069
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1089..1163
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1165..1240
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1249..1324
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1325..1400
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1401..1475
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1476..1550
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT REGION 615..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1729 AA; 191907 MW; 87E4375682D7E2DE CRC64;
MEGNGTENPC SRTLGWLQQD NDAKPWLWKF SNCFSRPEQT LPLSPQTKDY MENKKVAVEL
KDVPSPLHAG SKLFPAVPLP DIHSLQQPKI QLSTVPKVSC CAHCTNEPST SPMHTGSLIH
SGALLDSQST RTITCQVGSG FAFQSASSLQ NASARNNLAG IASDFPSMCL ESNLSSCKHL
PCCGKLHFQS CHGNVHKLHQ FPALQGCPSA TGYFPCSDFT SGAPGHLEEH ISQSELTPHL
CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQT APVAIPLCNG
CGTKGTGKET TLLLATSLGK PASKFGSPEV AVAGQMLENL PPIGVFWDIE NCSVPSGRSA
TAVVQRIREK FFKGHREAEF ICVCDISKEN KEVIQELNNC QVTVAHINAT AKNAADDKLR
QSLRRFANTH TAPATVVLVS TDVNFALELS DLRHRHGFHI ILVHKNQASE ALLHHANEQI
RFEEFISDLP PRLPLKMPQC HTLLYVYNLP ANKDGKSISN RLRRLSDNCG GKVLSITGCS
AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSSAIAD KVKSPKKLKN
LKLCLIKDAS EQASSAKATP GKGLQANSGS ATKNANVKSL QELCRMESKT ANRNSEPQQG
NTRLAAPPHS NSSAAVPTYK NLGMAESVYK GNQKKENLSA RSVTSSPVER KDKEETMFQV
SYPSAFSKLI VSRQVGPLLT SQSWSSRNMS PNLLNRASPL AFNVANSSSG ADCPDPFANG
ADIQISNIDY RLSRKELQQL MQEAFSRHGK VKSVELSPHT DYQLKAVVQM ETLQEAISAV
NSLHRYKIGG KKILVSLATG ATNKSLSLLS AETMSILQDA PACCLPLFKF TDIYEKKFGH
KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS SQSHDGSSAN CSPIIFEELE
YHEPVCRQHC SNKEFSEHEF DPDSYKIPFV ILSLKTFAPQ VHSLLQTHEG TVPLLSFPDC
YAAEFGELEV IQENRGGVPL EHLITCVPGV NIATAQNGVK VLKWIHNKPP PPNADPWLLR
SKSPVGNPQL IQFSREVIDL LKNQPFCVTP ISNFIPSYHH HFAKQCRVSD YGYSKLIELL
EAVPHVLQIL GMGSKRLLTL THRAQVKRFT QDLLKLLKSQ ASKQVIVREF SQAYHWCFSK
DWDVTEYGVC ELTDILSEIP DTTISLSQQD NEMVICIPKR ERTQDEIERT KQFSKDVVDL
LRHQPHFRMP FNKFIPSYHH HFGRQCKLSY YGFTKLLELF EAIPDILQVL ECGEEKILTL
TEVERFKALA AQFVKLLRSQ KDNCLMMTDL LTEYAKTFGY TFRLQDYDVS SISALTQKLC
HVVKVADMES GKQIQLINRK SLRSLTAQLL VLLMSWEGTT FLSVDALKRH YETTHSAPLN
PCEYGFMTLT ELLKSLPYLV EVFTNDKTEE CVKLTSLYLF AKNVRSLLHT YHYQQIFLHE
FPMAYAKYVG ETLQPKSYGY NSVEELLGAI PQVVWIKGHG HKRIVVLKND MKSRLSSLGL
SPANHESQLS DNERILEVPE SHIASKLNLG PGPSQTEQEL LRLTSSSPVD LLCEPVPSCL
PSPQLRPDPV ILQSADLIQF EEHPQDPSEI MILNQEENIE IPVPIKNEQL TSGSRSECVS
AAAPEPPCPS SEAPESLPSK DPVESPAKKQ PKNRVKLAAN FSFAPVTKL
//
