ID G3U3P8_LOXAF Unreviewed; 845 AA.
AC G3U3P8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000022456.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000022456.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022456.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000022456.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022456.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3U3P8; -.
DR STRING; 9785.ENSLAFP00000022456; -.
DR Ensembl; ENSLAFT00000034471.1; ENSLAFP00000022456.1; ENSLAFG00000026668.1.
DR eggNOG; ENOG502S92U; Eukaryota.
DR GeneTree; ENSGT00940000161714; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; G3U3P8; -.
DR OMA; QNYLEHL; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF14; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 5..203
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT COILED 811..842
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 845 AA; 95751 MW; 0C3403194E34FCC0 CRC64;
SSKPHTVVLQ GPAGVGKTTL AKKLMLDWTR DNFGKAFKYA FYLSCKELNH MGPRTCAELI
SKDCPELQDA ILEVLDRSQR ILIIVDGFDE LRFPPGALIS DMCGDWKKQK PVAVLLSSLL
TRRMFPKATL LITTRPWAMR ELWFLVERPF FIDIEGFLEV DKKEYFLKHF QDEDQALRAF
NLMRGNTALF SLGSAPMVCW VVCTCLKLQM DKGEDPTPTC QTTTSLFLRF ICSQFMPVPD
SCPDQCFQAP VKALCLLAAE GVWTQTSVFD GEDLERLGVK ECELSPFLDK NILQKVKGCE
GCYSFIHLSV QQFFAAIFYV LGSEEEKEDR ESHREDIGNI QKLLSKEERL KNPSLPQVGY
FLFGLSNEKR TRELETTFGC QLSIDVKQEL LRWKVKSNEN KPFSVLDMKD VFYCFYESQK
EQFVKDAMAH FREVSLKLKN ETDIVHASFC LKHCQNLEKI SLKYSSSLPH RSQRDYRILP
LWVDLCSVVN LNKNLSVLDV SDSFLSDTSV RILCERMARV TCNLQKVVIK NVSPVDAYRD
FCLALVGKTT LTHLILEGSV HSEKMLLLLY EALRHSKCNL QFLRIEMCSS TCSVTTYMIL
SCFLTHKTKL VRIINRRSFQ LSLSLQYLNS TNFGPDCLDI SNFLLGSCAA IAEEWECLFS
GLELNQSLTC LNLTDSELSV EDVKLLCAAL KHPNCSLRML SLENCHLTEA SCKDLSSALI
INQKLTHLSL AKNELGDGGV QLLCEGLSYP DCKLQTLVLW GCSITTLCCQ DLASALINNE
SLETLDLGEN ILGQSGVTVL LEALKQKKGF LQKLRLTIDE SNVETQKLLE ELKERNPQLT
IECSD
//
