ID G3U459_LOXAF Unreviewed; 246 AA.
AC G3U459;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Eukaryotic translation initiation factor 4H {ECO:0000256|ARBA:ARBA00013856};
GN Name=EIF4H {ECO:0000313|Ensembl:ENSLAFP00000022617.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000022617.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000022617.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022617.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000022617.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022617.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Stimulates the RNA helicase activity of EIF4A in the
CC translation initiation complex. Binds weakly mRNA.
CC {ECO:0000256|ARBA:ARBA00025462}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
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DR AlphaFoldDB; G3U459; -.
DR STRING; 9785.ENSLAFP00000022617; -.
DR Ensembl; ENSLAFT00000026739.1; ENSLAFP00000022617.1; ENSLAFG00000010578.3.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000155414; -.
DR InParanoid; G3U459; -.
DR OMA; ECKGGWD; -.
DR TreeFam; TF313897; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0019953; P:sexual reproduction; IEA:Ensembl.
DR CDD; cd12401; RRM_eIF4H; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034229; eIF4H_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23236; EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H; 1.
DR PANTHER; PTHR23236:SF117; EUKARYOTIC TRANSLATION INITIATION FACTOR 4H; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 42..118
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 122..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 27194 MW; 35BA02920750C04F CRC64;
MHSFRTGDFC ILLGVGVGIW SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA
IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK
QDKGGFGFRK GGPDDRGMSG SRESRGRWGS RDDSGFRDDF LGGRGGSRPG DRRTGPPMGS
RFRDGPPLRG SNMDFREPTE EERAQRPRLQ LKPRTVATPL NQVANPNSAI FGGARPREEV
VHKEQE
//
