ID G3U4K5_LOXAF Unreviewed; 675 AA.
AC G3U4K5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Oligophrenin 1 {ECO:0000313|Ensembl:ENSLAFP00000022763.1};
GN Name=OPHN1 {ECO:0000313|Ensembl:ENSLAFP00000022763.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000022763.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000022763.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022763.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000022763.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022763.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynapse {ECO:0000256|ARBA:ARBA00034110}.
CC Presynapse {ECO:0000256|ARBA:ARBA00034106}.
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DR AlphaFoldDB; G3U4K5; -.
DR Ensembl; ENSLAFT00000034873.1; ENSLAFP00000022763.1; ENSLAFG00000009683.3.
DR GeneTree; ENSGT00940000160157; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF2; OLIGOPHRENIN-1; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 137..240
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 252..437
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 439..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..628
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 76994 MW; 7CE49BB7D644D7E3 CRC64;
ERKKKFEKDG ERFYSLLDRH LHLSSKKKES QLQEADLQVD KERRNFFESS LDYVYQIQEV
QESKKFNIVE PVLAFLHSLF ISNSLTVELT QDFLPYKQQL QLSLQNTRNH FSSTREEMGE
LKRRMKEAPQ TCKLPGQPTI EGYLYTQEKW ALGISWMKYY CQYEKETKTL TMIPMEQKPG
AKQGPLDLTL KYCVRRKTES IDKRFCFDIE TNERPGTITL QALSEANRRL WMEAMDGKEP
IYHSPITKQE EMQLDEVGFK FVRKCINVIE TKGIKTEGLY RTVGSNIQVQ KLLNAFFVDP
KCPGDVDFHN SDWDIKTITS SLKFYLRNLS EPVMTYRLHK ELVSAAKSDN LDYRLGAIHS
LVYKLPENNR EMLELLIRHL VNVCEHSQEN LMTPSNMGVI FGPTLMRAQE DTVAAMMNIK
FQNIVVEILI EHFDKIYSGP PEESTAPPVP PPRVTARRHK PITISKRLLR ERTVFYTSSL
HESKDEIQHQ TPNGTITSST EPHKLPQHPK LPAQRFGEAD PGRKSPSRPI SDSKLEPCPE
VDMGKLLSRL QDGGTKATLK ATNGPMSGPG PTKVSSFHVK RPAPRPLAHQ KEGDSNSFSK
VRPLGEKPTI IRPPVRPPDP PCRAATPQKP EPKPDIVAGS AEEIPSSVVA SRTRFFETAS
RKTGSSLRKA PISEV
//
